Xtandi + Zytiga Fails To Deliver

[gusgold]

Looks Like Myers was wrong about 2 better than 1 but I wonder if the combination would give a longer time to progression to mCRPC

Gus

urotoday.com/recent-abstrac...

[pjoshea13]

Gus wrote:

"Looks Like Myers was wrong about 2 better than 1"

Myers didn't actually say that. What he did say was that protocols that are effective in other cancers all involve multiple therapies. Perhaps three or more.

When Xtandi after Zytiga showed disappointing results, & vice versa, there were experts on the sidelines saying that the results were not unexpected. The reason being the anticipated overlap in the reasons for drug resistance - because both drugs essentially have the same target.

If one fails Lupron, one is categorized as being castrate resistant. But Xtandi & Zytiga are castration drugs too. One targets an alternative source of androgen, while the other blocks the androgen receptor directly. In the cited study, the men were already CRPC cases, which means that some might not have responded to the other drugs, or might have responded poorly.

The Myers concept, which seems to be novel only in the PCa world, is to hit the cancer from several directions. PCa researchers seem mostly intent on shutting down any androgen escape pathway.

Before CRPC, we had terms like 'androgen refractory'. It eventually came as a surprise that the AR continued to be a player in advanced PCa. Researcers who had been stymied suddenly realized that ADT was failing because the patient wasn't castrate enough.

My feeling is: Enough with the castration!

But if we are going to continue down that road, why do the trials never include a statin? & shouldn't Avodart be included too? & so on. Let's close all the barn doors we can.

&, ideally, this should coincide with ADT initiation - not failure.

-Patrick

[Dan59 in reply to pjoshea13]

Great answer Patrick, I often wonder if I should return to a statin. Strange as it may be I have been hammering on the AR with many different drugs for a long time. and switching did give response in most cases, though now I slowly climb the steps with times going down a flight.

[gusgold in reply to pjoshea13]

Myers did say it...he was talking about blocking PCa drug resistance and said Xtandi for the AR receptor and Zytiga to block access to cholesterol

Gus

[Daddyishealing in reply to gusgold]

Can you point me to a study on relation to cholesterol meaning help me understand scientifically with the castration. I did read about statins, but for some reason , my brain is iverliaded, and I only retained the bottom line. ty, as always for these informative posts

[pjoshea13 in reply to gusgold]

But Zytiga doesn't block cholesterol. It blocks pregnenolone & progesterone from converting to androgens. Was he suggesting that this takes cholesterol out of the picture in terms of steroidogenesis?

Was this in a vblog post?

As we discovered, resistance mechanisms were similar for both drugs. Which limits their value when used in sequence - or together.

-Patrick

[GAdrummer]

The abstract omitted important information. The crucial point here is that the study participants's PCa had already activated pathways to work-around Xtandi so the addition of Zytiga was not helpful since its action is so similar to Xtandi. What the abstract omitted was what was the response to just the Zytiga and prednisone after the Xtandi.

[JoelT]

Gus,

The answer to your question is actually as simple as the question itself, we can not know because the study did not ask this question. All we do know from the study is that the combination of these drugs does not have a positive effect on progression free survival. It does not even tell us if there is a change in progression itself.

Joel

[Jvaughan0]

Hi, Nakakrats. Would you share which supplements you are taking. I'm on Lupron now as I get ready for salvage radiation in a few weeks. I'm consuming lots of soy products and taking 5000 units of D3 daily now.

Thanks

[Jvaughan0]

[e-mail]

[Jbooml]

Hi again Nalakrats

I like the way you think...I’m new to the forum and feel that the polymutational ability of PC demands multiple fronts of attack...I can’t get very good care where I live in Canada and being astronomically highgrade have taken upon myself to look for anything and everything to save myself. currently I’m supplementing with yew berries and turmeric and am managing to hang in. I’d like to find a doc willing to help me with off labels but my closest oncologist is 500 miles away. I’m going to beat this thing if I have to travel to Germany at last resort for act225 radioligand treatment. I am committed to my recovery at any cost and anyone standing in my way better be ready to fight a wildcat.

[Jbooml]

Holy S#*t

Knew it was bad but what you describe is jaw dropping....you’ve been around awhile...noticed you might be lining up for lu177...is this courtesy of endocyte/Novartis?

Speak truth to power

Luv ya man