Cells were treated with ARN-509 (50 µM) alone or in combination with the autophagy inhibitors 3-methyladenine (3MA, 5 mM) or chloroquine (Chl, 20 µM) or with ATG5 siRNA knock-down.
The combination of 50 µM ARN-509 with autophagy inhibitors produced a further increase in cell death by day 7.
Interesting. I wonder how much Chloroquine should you take as a human to get a "significantly elevated antitumor effect" as mentioned in the article .
promising against soft tissue and bone metastasis: AMG 509
Feeling depressed about your PCa treatment, perhaps you could persuade you MO to give you Sertraline
#AskChatGPT : list of immunotherapy drugs for prostate cancer
Merck aims for prostate cancer dominance with 3 new phase 3 Keytruda studiesNiclosamide phase 1 b trial showing more promise for CRPC than phase 1 trial
