Xtandi side effects?

[ellie2211]

Hi all ,

Have you had a tingling/prickly itchy feeling under your skin with xtandi? I'm wondering if anyone has tips managing this, if it eventually went away, or if anyone has more knowledge about this particular side effect? Could it be an allergic reaction?

My dad feels very itchy, he says it intensifies when he moves around and his body temp goes up. It is really bothersome, lotions do not seem to help.

....Really hoping he's not allergic, he just started xtandi.

Thank you guys for your input!!

-Ellie

[Tall_Allen]

Let his oncologist know. He may be having an allergic reaction to Xtandi. He may want to check liver enzymes.

[ellie2211 in reply to Tall_Allen]

Thank you tall_allen,

I wonder if his liver might have something to do with it.... He has also started to experience high cholesterol this last month. (High levels began slightly before starting xtandi)

He is on xgeva and lupron too, is this common?

He will be asking for the liver enzymes test.

[Tall_Allen in reply to ellie2211]

What did his oncologist say when you told him?

[ellie2211 in reply to Tall_Allen]

He has his appointment in a few weeks, I'll update here

[ellie2211 in reply to ellie2211]

His onc said it is a possible allergy to lupron and told him to take Zyrtec Claritin or Allegra

[afab]

I’ve been on Xtandi for over 5 year with several side effects but never the ones your dad is experiencing. The allergy suggestion seems to be a good one. Check with dad’s onc.

[ellie2211 in reply to afab]

Thank you for your feedback, he has a phone appointment later next month and will ask about the side effects he is experiencing. I hope there is a way to manage and that it isn't his liver either.

5 years wow! Great to hear such great results

[larry_dammit]

Check out his pain pills, there are a lot of them that cause neuropathies, the opioids are among them. I had to go to the morphine based pills for pain the get rid of the pain . Fighting the monster 🙏🙏🙏

[j-o-h-n]

From Google search:

What Are Side Effects of Xtandi?

Side effects of Xtandi include:

numbness/burning pain/tingling/prickly feeling under your skin,

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 04/26/2020 1:47 PM DST

[ctarleton]

If the tingling/itching is there for long periods at a time, it is likely a side effect or a reaction involving a drug and/or nerve endings. As already suggested by others, tell the doctor.

If it seems to come on just before he may feel overheated, or just before having a hot flash, it might be related to a hot flash manifestation? After I was on Lupron for over 2-3 years, and especially after adding Xtandi about 3 years ago, I started feeling a kind of "aura" skin sensation that would happen shortly before a hot flash would fully kick-in. When I am in bed having just covered up, or starting to feel a bit overheated, I sometimes get a prickly, tingling skin sensation that starts around the back of my rib cage and seems to move forward around both sides of my torso to meet in the center of my torso. By the time it gets there, I often start to break out in the light sweat of a hot flash over most of the rest of my body. That's when I throw off the covers if in bed, remove layers of clothing, or seek out a nice cooling breeze or fan to help cool me down until the hot flash subsides after several minutes. I speculate that the "aura" I feel is associated with thousands of tiny sweat glands being stimulated to "do their thing" at the beginning of a hot flash episode. For me, it's not painful, ... just different.

Charles