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Melatonin as potential Covid-19 adjuvant treatment

Graham49 profile image
16 Replies

COVID-19: Melatonin as a potential adjuvant treatment

Author links open overlay panelRuiZhangaXuebinWangaLengNiaXiaoDiaBaitaoMaaShuaiNiuaChangweiLiuaRussel J.Reiterb

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doi.org/10.1016/j.lfs.2020.... rights and content

Abstract

This article summarizes the likely benefits of melatonin in the attenuation of COVID-19 based on its putative pathogenesis. The recent outbreak of COVID-19 has become a pandemic with tens of thousands of infected patients. Based on clinical features, pathology, the pathogenesis of acute respiratory disorder induced by either highly homogenous coronaviruses or other pathogens, the evidence suggests that excessive inflammation, oxidation, and an exaggerated immune response very likely contribute to COVID-19 pathology. This leads to a cytokine storm and subsequent progression to acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) and often death. Melatonin, a well-known anti-inflammatory and anti-oxidative molecule, is protective against ALI/ARDS caused by viral and other pathogens. Melatonin is effective in critical care patients by reducing vessel permeability, anxiety, sedation use, and improving sleeping quality, which might also be beneficial for better clinical outcomes for COVID-19 patients. Notably, melatonin has a high safety profile. There is significant data showing that melatonin limits virus-related diseases and would also likely be beneficial in COVID-19 patients. Additional experiments and clinical studies are required to confirm this speculation.

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Graham49
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LearnAll profile image
LearnAll

The abstract ending with "this speculation" makes me think why authors are calling it "speculation"

cesces profile image
cesces

The door has an error in it.

Can you repost it please

Graham49 profile image
Graham49 in reply tocesces

COVID-19: Melatonin as a potential adjuvant treatment

Author links open overlay panelRuiZhangaXuebinWangaLengNiaXiaoDiaBaitaoMaaShuaiNiuaChangweiLiuaRussel J.Reiterb

Show more

doi.org/10.1016/j.lfs.2020.... rights and content

Abstract

This article summarizes the likely benefits of melatonin in the attenuation of COVID-19 based on its putative pathogenesis. The recent outbreak of COVID-19 has become a pandemic with tens of thousands of infected patients. Based on clinical features, pathology, the pathogenesis of acute respiratory disorder induced by either highly homogenous coronaviruses or other pathogens, the evidence suggests that excessive inflammation, oxidation, and an exaggerated immune response very likely contribute to COVID-19 pathology. This leads to a cytokine storm and subsequent progression to acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) and often death. Melatonin, a well-known anti-inflammatory and anti-oxidative molecule, is protective against ALI/ARDS caused by viral and other pathogens. Melatonin is effective in critical care patients by reducing vessel permeability, anxiety, sedation use, and improving sleeping quality, which might also be beneficial for better clinical outcomes for COVID-19 patients. Notably, melatonin has a high safety profile. There is significant data showing that melatonin limits virus-related diseases and would also likely be beneficial in COVID-19 patients. Additional experiments and clinical studies are required to confirm this speculation.

cesces profile image
cesces in reply toGraham49

DOI Not Found

10.1016/j.lfs.2020.117583Get

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Graham49 profile image
Graham49 in reply tocesces

It's on google scholar and easily found with a search of the title.

cesces profile image
cesces in reply toGraham49

It is this

DOI:

10.1016/j.lfs.2020.117583

Instead of this;

DOI:

10.1016/j.lfs.2020.117583Get

I just doubled my nightly melatonin from 20 to 40 mgs. Slept well . Good post . Thanks

j-o-h-n profile image
j-o-h-n in reply to

I fell asleep before I took mine.....

Good LucK, Good Health and Good Humor.

j-o-h-n Monday 04/13/2020 7:26 PM DST

Report

in reply toj-o-h-n

Then luckily you have no need for it ..zzzzzz

j-o-h-n profile image
j-o-h-n in reply to

Only if I want to stay awake..........YAWN........

Good LucK, Good Health and Good Humor.

j-o-h-n Tuesday 04/14/2020 10:39 PM DST

j-o-h-n profile image
j-o-h-n in reply to

What’s the difference between light and hard?

It’s easy to get to sleep with a light on.

Goodnight..

Good LucK, Good Health and Good Humor.

j-o-h-n Tuesday 04/14/2020 11:21 PM DST

in reply toj-o-h-n

Tell me about it . I’m in full night wood all night tripping to pee. The new led toilet light is a charm . Like dancin into the disco .The prob is that during daylight not a pep from Pepe. I always was a night owl after working the night shift a couple years .

GeorgeGlass profile image
GeorgeGlass in reply to

wow 20-40mg. I was wondering if 300mcg was too much for me? Are you on ADT? Does your blood glucose rise because of this level of melatonin?

in reply toGeorgeGlass

Yes I’m on Tak-700. It stops adrenal production of T. I chopped the boys in 2017.. all of my blood work is super good .

GeorgeGlass profile image
GeorgeGlass in reply to

That's good about your blood work. Do you eat meat or poultry? My WBC and RBC are always low.

in reply toGeorgeGlass

I eat meat and poultry very rarely . Once you stop it’s hard to go back . Too hard to digest .

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