Random trial reported below. Not Coronavirus but may reduce viral load in throat which has been reported to be initially high in the throat for Coronavirus, see second extract. Gargling with salt water is common in UK for throat infections. If I get a sore throat I think I will try gargling with a high alcoholic drink. I've just tried this with Gin and it wasn't unpleasant.
Am J Prev Med. 2005 Nov;29(4):302-7.
Prevention of upper respiratory tract infections by gargling: a randomized trial.
Satomura K1, Kitamura T, Kawamura T, Shimbo T, Watanabe M, Kamei M, Takano Y, Tamakoshi A; Great Cold Investigators-I.
Author information
Abstract
BACKGROUND:
Gargling to wash the throat is commonly performed in Japan, and people believe that such hygienic routine, especially with gargle medicine, prevents upper respiratory tract infections (URTIs). Its effectiveness, however, has not been established by clinical trials.
DESIGN:
Randomized controlled trial carried out in 2002-2003 winter season and analyzed in 2003 and 2004.
PARTICIPANTS:
Healthy volunteers (387) aged 18 to 65 years.
INTERVENTION:
Participants were randomly assigned to water gargling, povidone-iodine gargling, and usual care (control). Subjects in the two gargling groups were requested to gargle with water or diluted povidone-iodine at least three times a day. Participants were followed for 60 days.
MAIN OUTCOME MEASURES:
The primary outcome measure was first URTI incidence. Severity of URTI symptoms among incident cases was also evaluated. Both outcomes were assessed with a self-administered symptom record. Analyses were performed on an intention-to-treat basis.
RESULTS:
A total of 130 participants contracted URTIs. The incidence rate of first URTI was 0.26 episodes/30 person-days among control subjects. The rate decreased to 0.17 episodes/30 person-days in the water gargling group, and 0.24 episodes/30 person-days in the povidone-iodine gargling group. Respective incidence rate ratios against controls were 0.64 (95% confidence interval [CI]=0.41-0.99) and 0.89 (95% CI=0.60-1.33). A Cox regression (proportional hazard model) revealed the efficacy of water gargling (hazard ratio=0.60, 95% CI=0.39-0.95). Even when a URTI occurred, water gargling tended to attenuate bronchial symptoms (p=0.055).
CONCLUSIONS:
Simple water gargling was effective to prevent URTIs among healthy people. This virtually cost-free modality would appreciably benefit the general population.
PMID: 16242593 DOI: 10.1016/j.amepre.2005.06.013
Viral load of SARS-CoV-2 in clinical samples
Yang Pan
Daitao Zhang
Peng Yang
Leo L M Poon
Quanyi Wang
Published:February 24, 2020DOI:doi.org/10.1016/S1473-3099(...
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An outbreak caused by a novel human coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first detected in Wuhan in December 2019,1 and has since spread within China and to other countries. Real-time RT-PCR assays are recommended for diagnosis of SARS-CoV-2 infection.2 However, viral dynamics in infected patients are still yet to be fully determined. Here, we report our findings from different types of clinical specimens collected from 82 infected individuals.
Serial samples (throat swabs, sputum, urine, and stool) from two patients in Beijing were collected daily after their hospitalisation (patient 1, days 3–12 post-onset; patient 2, days 4–15 post-onset). These samples were examined by an N-gene-specific quantitative RT-PCR assay, as described elsewhere.3 The viral loads in throat swab and sputum samples peaked at around 5–6 days after symptom onset, ranging from around 104 to 107 copies per mL during this time (figure A, B). This pattern of changes in viral load is distinct from the one observed in patients with SARS, which normally peaked at around 10 days after onset.4 Sputum samples generally showed higher viral loads than throat swab samples. No viral RNA was detected in urine or stool samples from these two patients.