"In contrast to Warburg's original hypothesis ..."

[pjoshea13]

New paper below [1].

If the first paragraph of a web page contains a reference to "Otto Warburg" & "Nobel Prize", get ready for nonsense. Oops!

But this is different:

from "Tumour Metabolism and Its Unique Properties in Prostate Adenocarcinoma"

"... the unique metabolic properties of prostate adenocarcinoma are likely to stem from the distinct metabolism of the prostatic epithelium from which it emerges. Normal prostatic epithelium employs comparatively glycolytic metabolism to sustain physiological citrate secretion, whereas prostate adenocarcinoma consumes citrate to power oxidative phosphorylation and fuel lipogenesis, enabling tumour progression through metabolic reprogramming."

Some might recall that the reason the healthy prostate takes up high levels of zinc, is that it protects the high uptake of citrate from being used as described above. PCa down-regulates zinc transporters that take zinc into cells. I don't believe that we have to give up on zinc, though, & I take 50mg zinc citrate daily. See [2].

-Patrick

[1] pubmed.ncbi.nlm.nih.gov/321...

Abstract:

"Anabolic metabolism mediated by aberrant growth factor signalling fuels tumour growth and progression. The first biochemical descriptions of the altered metabolic nature of solid tumours were reported by Otto Warburg almost a century ago. Now, the study of tumour metabolism is being redefined by the development of new molecular tools, tumour modelling systems and precise instrumentation together with important advances in genetics, cell biology and spectroscopy. In contrast to Warburg's original hypothesis, accumulating evidence demonstrates a critical role for mitochondrial metabolism and substantial variation in the way in which different tumours metabolize nutrients to generate biomass. Furthermore, computational and experimental approaches suggest a dominant influence of the tissue-of-origin in shaping the metabolic reprogramming that enables tumour growth. For example, the unique metabolic properties of prostate adenocarcinoma are likely to stem from the distinct metabolism of the prostatic epithelium from which it emerges. Normal prostatic epithelium employs comparatively glycolytic metabolism to sustain physiological citrate secretion, whereas prostate adenocarcinoma consumes citrate to power oxidative phosphorylation and fuel lipogenesis, enabling tumour progression through metabolic reprogramming. Current data suggest that the distinct metabolic aberrations in prostate adenocarcinoma are driven by the androgen receptor, providing opportunities for functional metabolic imaging and novel therapeutic interventions that will be complementary to existing diagnostic and treatment options."

[2] healthunlocked.com/advanced...

[noahware]

From what I understand, PC has more of an "addiction" to fats than the "addiction" to sugar that some say is a hallmark of many cancers. But it seems that PC may have little or no need for dietary sources of lipids because it can rely on de novo fatty acid synthesis, making its own needed fats out of available amino acids.

Dietary sources of amino acids are of course not limited to what we think of as "protein foods." Amino acids are in everything we eat. But any ideas on ways to fight PC through restriction of foods with one or two specific amino acids? The one that I have heard a little about is methionine restriction, but don't really know if that avenue (or any other) is worth investigating further, as relates to the progression of PC.

[pjoshea13 in reply to noahware]

Selective amino acid restriction [SAAR] is easiest for those who limit formed-protein intake. The men who might try this without great inconvenience are those on a vegan diet.

Methionine seems like the best bet, but is not the only one. I haven't heard that anyone here is trying it. Absolutely worth considering when running out of options. OK, I know that some men facing death or a vegan diet would need time to think about it. LOL

-Patrick

[Hidden]

I do not know if this paper is by any way related to my amateurish research on "interfering with ATP Citrate Lyase (ACLY)". There is some "citrate" something key-word appearing on both of them.

healthunlocked.com/prostate...

I found 2-3 claims that HydroxyCitric Acid (HCA) can do the trick.

HCA can be found, in part, in the supplement Garcinia Cambogia. From a German poster, I learned that taking the former in combination with Alpha Lipoic Acid has made his PSA go down for two years.

I take a long list of supplements, so adding those two doesn't make any difference.

My PSA, for now, is low, so I don't anticipate detecting any measurable difference.

But, I will watch my cholesterol and 3glyceride counts to check whether it is working as claimed or not.

Will let you know when having some tangible evidence.

[pjoshea13 in reply to Hidden]

A note on Alpha Lipoic Acid [ALA]. I take a lot of polyphenols at fairly high levels. These antioxidants become pro-oxidants at high levels. The aim is induce reactive oxidant species [ROS]. ALA is regarded as a somewhat reliable antioxidant. i.e. it might negate the effect of the polyphenols. This would certainly be the case with NAC. Perhaps ALA at a certain dose would not do that, but I am wary.

-Patrick

[latvis]

Yeah, specific task- how to destroy Krebs cycle in cells.

Trying with oxidation.