Asbestos

[pjoshea13]

As best as I can remember, I never saw a study that associated asbestos exposure to PCa before a meta-analysis published last year [2]. And now we have another one [1].

"Asbestos exposure increased the risk of prostate cancer ... {by 10%}."

"Both environmental and occupational exposure increased the risk of prostate cancer (1.25 ... and 1.07 ... respectively).

"For type of fibers, the amosite group had an increased risk of prostate cancer (1.12 ...), and there were no significant results for the chrysotile/crocidolite group.

"The risk was higher in Europe (1.12 ...), without significant results in other continents." {!!!}

***

From the older study:

"The overall pooled {standardized mortality ratio} of PCa was 1.22".

***

We have no shortage of smoking guns & it is hard to keep track of all of them. Some days it seems that everything causes PCa.

-Patrick

[1] pubmed.ncbi.nlm.nih.gov/320...

Perm J

, 24 2020

Prostate Cancer and Asbestos: A Systematic Review and Meta-Analysis

Frédéric Dutheil 1 2 , Laetitia Zaragoza-Civale 3 , Bruno Pereira 4 , Martial Mermillod 5 6 , Julien S Baker 7 , Jeannot Schmidt 8 , Fares Moustafa 9 , Valentin Navel 10

Affiliations collapse

Affiliations

1 Physiological and Psychosocial Stress, Université Clermont Auvergne, CNRS, LaPSCo, CHU Clermont-Ferrand, University Hospital of Clermont-Ferrand, Occupational and Preventive Medicine, WittyFit, France.

2 Faculty of Health, School of Exercise Science, Australian Catholic University, Melbourne, Victoria.

3 Occupational and Preventive Medicine, CHU Clermont-Ferrand, University Hospital of Clermont-Ferrand, France.

4 Biostatistics Unit, the Clinical Research and Innovation Direction, CHU Clermont-Ferrand, University Hospital of Clermont-Ferrand, France.

5 Université Grenoble Alpes, Université, Savoie Mont Blanc, CNRS, LPNC, Grenoble.

6 Institut Universitaire de France, Paris.

7 Department of Sport, Physical Education, and Health, Centre for Health and Exercise Science Research, Hong Kong Baptist University, Kowloon Tong.

8 Physiological and Psychosocial Stress, Université Clermont Auvergne, CNRS, LaPSCo, CHU Clermont-Ferrand, Emergency Medicine, University Hospital of Clermont-Ferrand, France.

9 Emergency Medicine, Université Clermont Auvergne, CHU Clermont-Ferrand, University Hospital of Clermont-Ferrand, France.

10 Ophthalmology, Université Clermont Auvergne, CHU Clermont-Ferrand, University Hospital of Clermont-Ferrand, France.

PMID: 32097115 DOI: 10.7812/TPP/19.086

Abstract

Introduction: Asbestos-related diseases and cancers represent a major public health concern.

Objective: To conduct a systematic review and meta-analysis to demonstrate that asbestos exposure increases the risk of prostate cancer.

Methods: The PubMed, Cochrane Library, Embase, and ScienceDirect databases were searched using the keywords (prostate cancer OR prostatic neoplasm) AND (asbestos* OR crocidolite* OR chrysotile* OR amphibole* OR amosite*). To be included, articles needed to describe our primary outcome: Risk of prostate cancer after any asbestos exposure.

Results: We included 33 studies with 15,687 cases of prostate cancer among 723,566 individuals. Asbestos exposure increased the risk of prostate cancer (effect size = 1.10, 95% confidence interval [CI] = 1.05-1.15). When we considered mode of absorption, respiratory inhalation increased the risk of prostate cancer (1.10, 95% CI = 1.05-1.14). Both environmental and occupational exposure increased the risk of prostate cancer (1.25, 95% CI = 1.01-1.48; and 1.07, 1.04-1.10, respectively). For type of fibers, the amosite group had an increased risk of prostate cancer (1.12, 95% CI = 1.05-1.19), and there were no significant results for the chrysotile/crocidolite group. The risk was higher in Europe (1.12, 95% CI = 1.05-1.19), without significant results in other continents.

Discussion: Asbestos exposure seems to increase prostate cancer risk. The main mechanism of absorption was respiratory. Both environmental and occupational asbestos exposure were linked to increased risk of prostate cancer.

Conclusion: Patients who were exposed to asbestos should possibly be encouraged to complete more frequent prostate cancer screening.

***

[2] pubmed.ncbi.nlm.nih.gov/306...

Meta-Analysis Medicine (Baltimore)

, 98 (3), e14108 Jan 2019

Does Exposure to Asbestos Cause Prostate Cancer? A Systematic Literature Review and Meta-Analysis

Rui Peng 1 , Fang Fang 2 , Zhijun Chen 1 , Shuai Yang 1 , Changyuan Dai 1 , Chengyong Wang 1 , Han Guan 1 , Qingwen Li 1

Affiliations collapse

Affiliations

1 Department of Urology, The First Affiliated Hospital of Bengbu Medical College.

2 Department of Immunology, Bengbu Medical College, Bengbu, China.

PMID: 30653132 PMCID: PMC6370155 DOI: 10.1097/MD.0000000000014108

Abstract

Objective: The relationship between asbestos and prostate cancer (PCa) is not well understood due to small number of cases. This study aimed to determine the incidence and mortality of PCa among workers or residents exposed to asbestos based on a systematic review and meta-analysis METHODS: All published studies citing the standardized mortality ratio (SMR) or standardized incidence ratio (SIR) of PCa in workers or residents exposed to asbestos were collected by conducting a search on PubMed, EMBASE, Cochrane Library, and Web of Science before April 2018. Standardized mortality rate for PCa with its 95% confidence interval (CI) was pooled using a fixed-/random-effect model in STATA (Version14.0). This study is registered with PROSPERO, number CRD42018095195.

Results: A total of 17 independent studies were included for the analysis. The overall pooled SMR of PCa was 1.22, with a 95% CI of 1.13 to 1.32, with no heterogeneity across the studies (I = 18.8%, P = .234). Subgroup analysis shows that exposure to crocidolite, cement, studies conducted in Europe and Oceania, and long study follow-up (≥25 years) all contribute to significantly higher SMR, and we found no evidence of publication bias (Begg test P value = .592, Egger test P value = .874).

Conclusions: This meta-analysis suggested that exposed to asbestos might be associated with an increased risk of PCa. High-exposure level of asbestos could contribute to significantly higher risk of PCa mortality.