I discussed the Celebrex + Zometa combo with my MO (in the context of ~20% lower mortality rate in metastatic setting), and he suggested I take Denosumab (no Celebrex). I see studies comparing Denosumab to Zometa, but I don't see anywhere comparing it to the combo of Celebrex and Zometa, or used by itself in a combo. My MO is sort of open to my choice of the two. Any thoughts?
Denosumab vs Celebrex and Zometa - Advanced Prostate...
Denosumab vs Celebrex and Zometa
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snoraste
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They only studied Zometa±Celebrex. The combination of Xgeva and Celebrex has never been tested but may work similarly. Zometa has consistently shown no survival advantage when used alone. I assume the same will be true for Xgeva. Why wouldn't he prescribe Celebrex for you?
I did not ask. I'm sure he'll be open to it. I though because the mechanism of action (as I understand it) is different between the two (RANKL inhibitor vs bisphosphonate), Celebrex perhaps is not needed?
Celebrex is only needed to extend survival and to reduce inflammation . I have no idea if the mode of action makes a difference for survival when combined with Celebrex , but I can’t think of a reason not to unless NSAIDs are a problem for you.
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