Two new drugs finally hit ‘undruggable’ cancer target, providing hope for treatments

[Pierreb]

Happy New Years Gentleman!

I came across this article the other day. It does not address prostate cancer directly but I thought I would share just in case this is helpful. I am hoping that this can someday be used on Prostate Caner.

"Cancer researchers are making progress toward a goal that has eluded them for more than 30 years: shrinking tumors by shutting off a protein called KRAS that drives growth in many cancer types. A new type of drug aimed at KRAS made tumors disappear in mice and shrank tumors in lung cancer patients, two companies report in papers published this week."

sciencemag.org/news/2019/10...

[6357axbz]

Thanks

[Graham49]

This study indicates that KRAS is involved with PCa metastasis. Therefore the KRAS inhibitors in the above study may well be useful for PCa.

Research

Open Access

Published: 05 September 2019

MAZ promotes prostate cancer bone metastasis through transcriptionally activating the KRas-dependent RalGEFs pathway

Qing Yang, Chuandong Lang, Zhengquan Wu, Yuhu Dai, Shaofu He, Wei Guo, Shuai Huang, Hong Du, Dong Ren & Xinsheng Peng

Journal of Experimental & Clinical Cancer Research volume 38, Article number: 391 (2019) Cite this article

587 Accesses

1 Citations

Abstract

Background

Clinically, prostate cancer (PCa) exhibits a high avidity to metastasize to bone. Myc-associated zinc-finger protein (MAZ) is a well-documented oncogene involved in the progression and metastasis of multiple cancer types, even in PCa. However, the clinical significance and biological roles of MAZ in bone metastasis of PCa remain unclear.

[Pierreb in reply to Graham49]

Thanks Graham49 for the info! I'm glad to hear that this may someday be another method to fight PCa. Hope you good holiday!