Beyond PSMA - FAPI theranostics

[Tall_Allen]

I usually don't cover diagnostic/therapeutic (theranostic) developments until there is extensive data from clinical trials. Now that we are starting to understand the limitations of PSMA theranostics, it may give us hope to know about the next big thing coming down the pike. To understand it may involve a mental adjustment for some of us in how we conceive cancer. I've tried to explain it as simply as possible (but there is still a lot of technical jargon that will be unfamiliar to most of us).

pcnrv.blogspot.com/2019/12/...

[tallguy2]

Thanks for posting this!

[Lrv44221 in reply to tallguy2]

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LRV

[caltexman]

Last year theranostics was the buzz word on the road to making metastatic prostate cancer a chronic disease like diabetes. Recognition that eliminating PSMA sensitive cancer cells with targeted radioactive agents may "make room" for other mutated cancer sells without PSMA has tampered the excitement this year. The article you referenced: "However, the concept of double therapeutic targets is potentially useful for prostate cancer, where both PSMA and FAPI may be targeted." BINGO! New FAP inhibitor (FAPI) drugs and radiation therapies are the key that will overwhelm prostate cancer's ability to mutate to survive and kill the host (us). Better scans coming using this technology will make it feasible to "Whack-A-Mole" stroma tumors as well as solid tumors.

[cesanon]

1. Nice article.

2. It would seem that Lu-177-FAPI might be very dangerous to control and could attack lots of things you don't want attacked.

3. How soon do you expect FAPI-targeted PET indicators to start being available in Germany, at least under clinical trial conditions?

[Tall_Allen]

1. Thanks.

2. FAP is very specific to cancer

3. UCLA will be doing an expanded trial next year. Germany has been doing some pilot studies, as described.

[Escudilla]

Excellent. Thanks Allen!

[Fdccs]

Great, bring on the science.

Thanks for posting

[Break60]

Allen

Thanks . Great to see the depth of research being done!

Bob

[Tallshark]

I think this subject was already posted 6 months ago:

healthunlocked.com/advanced...

Just to refresh what was discussed at that time.

[GP24]

The FAPI tracer can also be used to diagnose rheumatoid arthritis:

up.picr.de/37482269ja.png

Here a patient with ankylosing spondylitis which was treated with IgG monoclonal antibody treatment. The image shows the benefit of the treatment:

up.picr.de/37482270iw.png

[RayF]

Thanks for the info and explanation.

[TheTopBanana]

Hi! What happened to this?

[Tall_Allen]

They are still working on the diagnostic end mostly. Several pharmaceutical companies are getting involved.

[lewicki in reply to Tall_Allen]

Any news?

[Tall_Allen in reply to lewicki]

It doesn't seem to be as good with PCa as it is with other cancers. MD Anderson has been focussing on fibroblast growth factor inhibitors like erdafitinib.