Understanding of PSMA scan and Radio ligand PSMA therapy

[Karmaji]

We all know about PSMA pet scan....

Recently my French ONCO was talking of Radio ligand PSMA therapy

which includes scan ??

Confusing to me....may be I am not expressing correctly

He says very recently FDA approved this therapy....

It is not pet image scan but therapy....interesting

[6357axbz]

LU177

[Karmaji in reply to 6357axbz]

What it does mean and what about toxicity....Will it become standard protocol ?

Or is it for last stage therapy....

[6357axbz in reply to Karmaji]

Google it. You can also use this blogs search routine. Quite a few of the men here are using it

[dhccpa in reply to 6357axbz]

Have you had good outcome with it?

[tango65]

Some info about Lu 177 PSMA treatment in castration sensitive and castration resistant PC:

thelancet.com/journals/lanc...

clincancerres.aacrjournals....

[Karmaji in reply to tango65]

Will this become standard treatment for any metastases stage....Why not...one may attack cancer cells before they evolve into measurable tumors...

Idea of all new precise scanning is to treat cancer in initial stage thus PC is curable...

[tango65 in reply to Karmaji]

I had this treatment in 2016 at the Technical University Munich. One treatment made all the lymph nodes mets PSMA negative and they have remained PSMA negative so far.

They do not treat what they can not see in a PSMA PET/CT. Some places, like in India they do a treatment without mets in a PSMA PET/CT but it may be risky since a lot of radiation could go to kidneys, gut , salivary glands in absence of metastases 4 to 5 mm or larger.

The treatment is very well tolerate some fatigue, transient dry mouth etc. People with large number of bone mets or diffuse infiltration of the bone marrow could have more side effects because of suppression of the bone marrow by the radiation.

[GP24 in reply to tango65]

The treatment destroyed the tumor cells in the affected lymph nodes. Therefore they turned negative on a PSMA PET/CT.

[Tall_Allen]

Not approved yet.

[MateoBeach]

If your PSMA scan had high values of uptake in cancer sites, then Lu-PSMA treatments may be of significant benefit. You can get them overseas now. And probably next year in the USA for mCRPC. So the PSMA on PC cancer cells can be useful both for imaging/diagnostics and for therapy with radio-ligands. That is why it is sometimes referred to as Theranostics.

[Karmaji in reply to MateoBeach]

Thanks Mateo....U hit the point...

Great... it is a bit unclear terrain...Would be very informative to follow what is Theranostics....

It is what we need....not only scanning but curing thru radioactive drugs...

Hopefully less toxic and reaching the real target without any scorched earth killing...

a game changer....

Theranostics is the term used to describe the combination of using one radioactive drug to identify (diagnose) and a second radioactive drug to deliver therapy to treat the main tumor and any metastatic tumors.

[Karmaji in reply to Karmaji]

My onco was talking of it, but he could not express it....