Met with my MO yesterday and we agreed to reduce my zytiga from 1000mg to 250 mg w yogurt (surprisingly, he said that some insurance companies were now requiring this!!)
He really didn't know about the details - so i'm assuming that my 4 oz activia is ok - and that i need to wait an hour until i have my oatmeal?
anyone know any differently??
thanks
Hi PabloK, here is a link to summary of a study that was done regarding taking Zytiga with and without a meal.
If you are reducing to only 250mg, I think you will want a high-fat breakfast. But absorption is highly variable from patient to patient and the studies are small.If you want to be sure you are getting the right amount, stick with 1000 mg and no food. Maybe send him these links:
accp1.onlinelibrary.wiley.c...
meetinglibrary.asco.org/rec...
I would sure like to now what insurance companies are now requiring this protocol. No hard data exists that shows the required absorption rate is obtained while taken with food. If your MO really didn't know about the details, I would be very leery regarding his advice. Many, many men have had great success using a 1000 mg of Zytiga a day on an empty stomach. Success that has lasted for many years. Be careful what you ask for.
Hello Daniel,
I have now been on a reduced Zytiga and prednisone dose for approximately nine months, it was my decision to so. The results have been very good and the PSA has and still is coming down, the last reading in November was 0.111.
I take the prednisone about an hour before the Zytiga, which I have always done, but the Zytiga (500 mg ) I take with a fried egg and bacon on toast, followed by a yoghurt. Absorption is the key, by increasing the absorption you don't need as much medication, better for you and your body.
Hope this helps.
Phil
Sorry I meant Pablok, it's early here 😂
My MO told me that taking one Zytiga/day with a low fat meal was more effective than taking four/day.
I’d say you are like the rest of us if you try. A one man clinical trial. I hope any of it works. Nobody is sure.
My husband had horrible side effects from taking the 1000 mg. We decided to cut the dose in half and he is hardly having any issues. His PSA is still dropping 0.19. We are sticking with this for now. Sometimes the medicine is worse then the disease.
Is he taking the half dose with food?
No without food. So far so good. He has a PSA drawn yesterday so we will see. He could not take the full strength of the drug. He could hardly walk, short of breath. Stopped working as he could not function. It was like he was being overdosed on it. The doctor said he only had one other patient that had such a bad reaction.
Wow sorry to hear and glad he’s doing better! Keep us posted on PSA results.
Thank all for sharing. I have been on abiraterone acetate since early July along with prednisone, and Lupron depot (quarterly). Outside of the annoying hot flashes, I am tolerating the medicine very well. All this is in addition to Xeralto for DVTs in both legs. In early December I was diagnosed with pulmonary hypertension and was given spironolactone (25 mg) and started it on Monday. Tuesday evening, after the second dose in the AM, Pam noticed that my face was turning yellow! We are beginning to suspect that my liver is having trouble processing all this medication. Yesterday I started taking the spironolactone on an every-other-day basis from some research that I found. Is anyone having trouble with the liver processing the load?
Would you please record some more info about yourself: Age, Location, psa/gleason scores, treatments to date, treatment center(s), doctor's names? All info is voluntary but it helps us help you and helps us too. Thank you...
I think it would be a good idea to re-post your question above in a future "subject post"...
Good Luck, Good Health and Good Humor.
j-o-h-n Friday 12/13/2019 5:57 PM EST
I also understand that the accompanying food should include some fat, equivalent to 8 oz. whole milk (3% milkfat). I have not been on this (yet) but would certainly try it as many have reported success. See T_A's links before deciding. An intermediate choice might be 250 mg twice daily with the food.
Zytiga 
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