Bad reaction after stopping abiraterone?

[NewGame]

Have any of you gentlemen had a bad reaction when stopping abiraterone? I’ve been in the current study for LU-PSMA-617 for the past 14 months; it’s evaluating the effectiveness of Pluvicto given at the beginning of the journey before chemo, but i’ve been in the control group. My last bone scan July 12, 2024 showed progression, so I’ll be crossing over into the active arm of the study in the coming weeks. MO said I could stop taking the abiraterone if I wanted to (although it could hypothetically still be doing some small good) because I would stop the drug when starting Pluvicto. So I stopped the abi.

By day 5 after I was in rough shape: bone and muscle aches everywhere; it was very hard to function. So I started the abiraterone again - and all is good. Anyone else have this experience?

Thank you

[NewGame]

meant June 12, 2024 for bone scan!

[NewGame]

and I was tapering off pred

[6357axbz]

No. I’ve stopped Abi twice for medication holidays with no issues.

Did you taper off the corticosteroid (prednisone or dexamethasone) you were taking with Abi. If not that can cause problems,

[NewGame in reply to 6357axbz]

I was beginning the slow taper of steroid

[Mormon1 in reply to NewGame]

Been on zytiga 7 years with just 5 mg Prendisone

[RyderLake2]

Hello,

I am in a very similar clinical trial investigating the effectiveness of Lutetium-177 pre-chemotherapy. Like you I was initially placed in the standard-of-care (SOC) control group. The clinical trial doctor wanted me to drop Xtandi (enzalutamide) which I had been taking for five years in favour of Zytiga (abiraterone) plus Prednisone. I was on that for a year. When my PSA started climbing I was allowed to crossover into the Lutetium arm. I have now completed three infusions with the fourth scheduled for the first week of August. When I crossed over to the Lutetium arm I was told by Cancer Agency doctors that I had to slowly wean myself off Prednisone. A pill every second day, half pills, 1/4 pills etc. The slower the process the better. The symptoms you describe might be a result of coming off the Prednisone too quickly. Good luck!

[NewGame in reply to RyderLake2]

Thank you! I was weaning very slowly off the steroid

[mrscruffy]

cold turkey on both Abi and Prednisone. No problems here, but everyone is different

[Mormon1 in reply to mrscruffy]

When hospitalized for covid 16 days no zytiga and prednisone. Testing week later. Lessthan 001

[gsun]

I went off Abi for three months. No issues.