Bad reaction after stopping abiraterone?

[NewGame]

Have any of you gentlemen had a bad reaction when stopping abiraterone? I’ve been in the current study for LU-PSMA-617 for the past 14 months; it’s evaluating the effectiveness of Pluvicto given at the beginning of the journey before chemo, but i’ve been in the control group. My last bone scan July 12, 2024 showed progression, so I’ll be crossing over into the active arm of the study in the coming weeks. MO said I could stop taking the abiraterone if I wanted to (although it could hypothetically still be doing some small good) because I would stop the drug when starting Pluvicto. So I stopped the abi.

By day 5 after I was in rough shape: bone and muscle aches everywhere; it was very hard to function. So I started the abiraterone again - and all is good. Anyone else have this experience?

Thank you

[NewGame]

meant June 12, 2024 for bone scan!

[NewGame]

and I was tapering off pred

[6357axbz]

No. I’ve stopped Abi twice for medication holidays with no issues.

Did you taper off the corticosteroid (prednisone or dexamethasone) you were taking with Abi. If not that can cause problems,

[NewGame in reply to 6357axbz]

I was beginning the slow taper of steroid

[Mormon1 in reply to NewGame]

Been on zytiga 7 years with just 5 mg Prendisone

[RyderLake2]

Hello,

I am in a very similar clinical trial investigating the effectiveness of Lutetium-177 pre-chemotherapy. Like you I was initially placed in the standard-of-care (SOC) control group. The clinical trial doctor wanted me to drop Xtandi (enzalutamide) which I had been taking for five years in favour of Zytiga (abiraterone) plus Prednisone. I was on that for a year. When my PSA started climbing I was allowed to crossover into the Lutetium arm. I have now completed three infusions with the fourth scheduled for the first week of August. When I crossed over to the Lutetium arm I was told by Cancer Agency doctors that I had to slowly wean myself off Prednisone. A pill every second day, half pills, 1/4 pills etc. The slower the process the better. The symptoms you describe might be a result of coming off the Prednisone too quickly. Good luck!

[NewGame in reply to RyderLake2]

Thank you! I was weaning very slowly off the steroid

[mrscruffy]

cold turkey on both Abi and Prednisone. No problems here, but everyone is different

[Mormon1 in reply to mrscruffy]

When hospitalized for covid 16 days no zytiga and prednisone. Testing week later. Lessthan 001

[NewGame in reply to Mormon1]

Glad you had no issues! Thanks for writing.

[gsun]

I went off Abi for three months. No issues.

[Mbnm]

newgame…hello from canada..i have advanced prostate cancer including lymph nodes

On abi,pred and lupron for one year so far great results except for all the disadvantages of low T

Did the abi and lupron not reduce yr psa hence move to Lu ?

Really interested in pluvicto without chemo which I assume would be my next step if my psa starts rising ?

Where can I read about the study u are in ?

Thanks

[NewGame in reply to Mbnm]

Hello. Thanks for writing. The abi and lupron failed after 12 months, leading to progression of my bone mets and a rise in my PSA to 54. That’s what has led to my crossing over in the study from the control group to the active arm. I don’t think the study is currently seeking participants, but if it’s successful it will hopefully lead to the FDA approving Pluvicto for use at the beginning of treatment pre-chemo. The following article is not an explanation of the study, but of the progress of the study up to this point.

“Novartis finally ready for Pluvicto filing in earlier prostate cancer as patient survival data clear up

By Angus Liu”

[NewGame in reply to Mbnm]

Sorry for delay - have been traveling.

I can’t get this doc to load here - if you send me your email I’ll send that way. There’s also an updated version of this doc I don’t have digitally.

[Mbnm]

pls see my reply to you