High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program

[KariMari]

Published: 25 September 2019 in Nature Communications volume 10, Article number: 4358 (2019)

nature.com/articles/s41467-...

[pjoshea13]

I'm sure that many who read the title walked away with the message that:

"High-fat diet fuels prostate cancer progression"

as though all fats are bioidentical.

A relief to see that the fat is narrowed down to "saturated" fat, but this includes lauric acid, myristic acid, palmitic acid, stearic acid (12, 14, 16 & 18 carbons) & others. [1]

From the into:

"increased consumption of saturated fat and obesity are linked with increased risk of prostate cancer progression and mortality"

A casual reading seems to connect saturated fat with obesity, which is very sloppy.

The mice were fed a 60%-fat feed, but I can't see which fats were included. There are saturated fats that are not found in a typical mouse diet, & I don't suppose that 60% fat is common too. It's not clear what bearing the diet has on those of us who follow a more prudent diet.

-Patrick

[1] en.wikipedia.org/wiki/Satur...

[FCoffey]

Another grotesquely mislabeled study. The very first sentence actually reads

Systemic metabolic alterations associated with increased consumption of saturated fat and obesity

It's not just diet, but being obese that is bad for the cancer. This is old news.

Reading further, they did not feed the mice a diet high in healthy fats. They fed them lard.

"a HFD (60% kcal from fat; lard—rich in saturated fat)"

Lard. Getting 60% of your calories from lard might be bad for you. We needed to pay for this study?

When I see a study where mice, or better yet people, are on a diet high in healthy fats, not lard, I might pay attention. This study is just noise, a worthless distraction.

[VictoryPC in reply to FCoffey]

Perfectly said...

[j-o-h-n]

KariMari you're gonna make me commit Harikari ......

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 09/28/2019 10:48 AM DST

[KariMari in reply to j-o-h-n]

Oh no! Haha. Yes, great humor: very important! Thank you.

[Jbooml]

Another un/lucky advantage for some of us bearing visceral vs adipose fat is its more measurable association with PC spread....not sure how one goes about measuring ones visceral endowment.