BAT like therapy

I have G9, hormone sensitive prostate cancer. Had an RP in 12/2018.

Estrogen therapy dropped my T down to zero. And my PSAs remained at zero. I did this for 5 months but stopped because of the side effects (felt great mentally but no libido and strength loss to the point that I wondered how long I could keep pursuing therapies). So I started casodex/dutasteride (150mg caso a day and 0.5mg duta). Libido is better than zero but still very very low. Strength loss seems to have reversed but perhaps too early to tell (I've been on this combo for 13 days).

What I am thinking of is a rotation of:

Caso/Duta

Estrogen

Supraphsyiological levels of testosterone.

Perhaps 1-2 months of each one? Benefit is that I'd have good or at least decent libido a third of the time. But I don't want to sacrifice health for libido so first I wanted to get opinions. And it is early but if the caso/duta continues acting like it does now then I can stay on it indefinitely. I'll monitor my PSA and perhaps my CEA and if there is a concern I can switch back to estrogen therapy.

[Break60]

Very interesting! Since I had no

Libido on trelstar casodex and dutasteride , when I switched to estradiol patches and stayed on dutasteride all I noticed was that all side effects were gone except libido had improved and boobs were sore. No impact on strength.

Does your doctor agree with what you’re planning or are you just doing it on your own? I frankly would be surprised if your PSA doesn’t rise when you drop estradiol. Let us know!

Good luck.

Bob

[Hidden in reply to Break60]

Lol! Just the opposite for me. Some libido now, lots of strength gain, and my gyno is going away. On estrogen the gyno was really bad.

My oncologist knows what I'm doing and is okay with it as long as I monitor my PSA regularly (I do that and also another 50 or so parameters).

SupraT will be interesting. I'll post updates.

[Break60 in reply to Hidden]

My Gyno is disappearing because I’m losing weight on purpose.

[Horse12888]

The recovery of your T takes at least 4 - 5 months, so switching things around more rapidly than that won't work.

If you want to learn more about bipolar ADT, follow the work being done at Johns Hopkins.

I strongly recommend against designing your own ADT regimen, especially with a G9.

[Hidden in reply to Horse12888]

Agree that I need to discuss with different doctors/researchers/etc. Most steps of the way I have to do that and will continue. Heck, even a "localized" G6 is very likely throughout your body but most of us will die of other causes.

I was relying on my tesoterone not recovering for at least a few weeks but 4-5 months is even better. I would want it to be castrate if exogenous testosterone is removed. Half lives play a big part but there are ways to decrease them. Again, all hypothetical though. I just talked to my oncologist and he advised me not to change anything at all since I'm still NED, my inflammation is negligible, my liver enzymes are low, and my PSAs are zero. I agree but I'm always trying to plan ahead so that I can quickly react to possible scenarios.