soy isoflavones not good for advanced PC

[Karmaji]

can we share recent studies though limited and not reliable that isoflavones should be avoided...

confusing...

[Tall_Allen]

"This study revealed that dietary intake of isoflavones was associated with an elevated risk of advanced prostate cancer."

onlinelibrary.wiley.com/doi...

It has been proven to have no effect in most situations. A randomized trial found that " Daily consumption of a beverage powder supplement containing soy protein isolate for 2 years following radical prostatectomy did not reduce biochemical recurrence of prostate cancer in men at high risk of PSA failure."

jamanetwork.com/journals/ja...

Nor did it reduce PSA in men with localized PC in this randomized trial:

ncbi.nlm.nih.gov/pmc/articl...

As for prevention, it was found to have no preventative effect in European men:

ncbi.nlm.nih.gov/pmc/articl...

onlinelibrary.wiley.com/doi...

However, It may be useful in conjunction with prostate radiation.

[Karmaji in reply to Tall_Allen]

Many thanks....

During radiotherapy...according to your information it may be useful....

Another question: Can you suggest diet regime to reduce organ damage during radio therapy..especially to rectum when cancer is out of prostate capsule, may be touching rectum and seminal canal......

What precaution are to be taken with IMRT IGRT ....

What do you think of Space OAR....not available it seems in France

[Tall_Allen in reply to Karmaji]

My friend is now going through chemo because of SpaceOAR, I suspect. I think it got into his extracapsular extension and pressed it against his rectal wall, protecting the cancer from radiation.

Do not make any radical dietary changes when undergoing prostate radiation. Such changes may stimulate bowel motility, which can move the prostate out of field and increase toxicity. Exercise is the best thing you can do for yourself.

[Karmaji in reply to Tall_Allen]

many thanks... so I go along normal IGRT/Imrt with lot of excercise

[Tall_Allen in reply to Karmaji]

Hypofractionated, if you can get it there:

pcnrv.blogspot.com/2018/10/...

[Karmaji in reply to Tall_Allen]

depending on favorable or not anatomy on dosimetric scan....

If non favorable a normo fractioned (french) dose may be used...all are 2 gays for 46 vesicule seminal left, 64 for vesicule seminal right and 76 for prostate

If favorable...I dont know what it means...60 gays with 3 gay.for prostate .48 boost for others....

I am not much familiar ... my only worry is how to reduce organ damage...

If you have any thought about reducing organ damage....

Thanks for caring replies....

[Tall_Allen in reply to Karmaji]

"1C: High risk men should be offered moderately hypofractionated IMRT."

Exercise to reduce organ damage.

[timotur in reply to Tall_Allen]

Or instead of SpaceOar, could have been that your friend's rectal invasion was due to metastasis to a mesorectal LN that wasn't detected by scans and not treated in radiation.

"Metastasization of mesorectal lymph nodes by a prostatic adenocarcinoma may be more frequent than expected."

sciencedirect.com/science/a...

[Tall_Allen in reply to timotur]

It was not lymph node invasion. He had full pelvic LN radiation. Even if it was, the problem remains that SpaceOAR can protect the cancer.

[blueCello]

I have read that any soy products should be avoided by anyone with sexual organ cancers. I'm not sure the scientists nor doctors particularly follow nor study nutrition. Our doctors here in the usa certainly don't think about it nor are they trained in medical school. It is so obvious; what we put in our bodies is fuel and is important. We can all buy Coconut Aminos to replace our soy sauces, yummy and complete meals. Worth a try.