Meds are working

[Drphil1938]

DX in March 2019 stage four, Gleason 9, one doctor indicated that with my 7 mets and lymph invasion that it was not good. I thought things were soon coming to an end. However, at the recommendation of a friend I sought out a MO at the Siteman Cancer Center in St. Louis

After meeting him and discussing options he started me on Cosadex for two weeks, then went to Lupron. Zytiga with predisone.

Results yesterday PSA 4.4 down from 99 in March, T <5 down from 460. I am pleased, happy and thankful for modern medicine, this web site and good advice given, plus J-O-H-N 's good humor.🤠

[pleinairpainter]

Great news, thanks for sharing. Keep up the good fight and please post your updates.

[dockam]

Congrats! Always so wonderful to hear a great response to Tx's.

Fight on Brother - Randy (Stage IV, Dx in 01/2015, PSA @ 840)

[GoBucks]

You are right that "it's not good" but that is precisely what has been successfully treated in many of us and why we simply have a chronic condition, not a death sentence.

[Drphil1938 in reply to GoBucks]

You are so right!!!

[Hidden]

Great attitude DrPhil...most of us are here due to modern medicine ..... great results so far ...keep on trucking . Welcome to the club. And yes , j-o-h-n is our best asset .. Carpe diem !

[j-o-h-n in reply to Hidden]

ASS-et?👀

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 07/24/2019 8:28 PM DST

[Hidden in reply to j-o-h-n]

Or ass man ? Which ever you prefer....

[j-o-h-n in reply to Hidden]

You pegged me.... I'm a from the waist down man.....

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 07/29/2019 4:39 PM DST

[Hidden in reply to j-o-h-n]

What a gentleman ?

[j-o-h-n in reply to Hidden]

youtube.com/watch?v=mzAfTmC...(Not working as expected?)

Well Well, Ladies and Gentlemen......... Lulu's back in town... Welcome back.

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 07/29/2019 9:52 PM DST

[Hidden in reply to j-o-h-n]

They don’t call you tri-pod for nuttin...

[j-o-h-n in reply to Hidden]

Now they call me a two legged tripod.....🤢🤢🤢

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 07/29/2019 9:53 PM DST

[Hidden in reply to j-o-h-n]

Dos, Soy nadie ,mucho gusto ...

[j-o-h-n in reply to Hidden]

Yo no hablo espanol, you hablo gringo....

Good Luck, Good Health and Good Humor.

j-o-h-n Tuesday 07/30/2019 12:14 PM DST

[Drphil1938 in reply to j-o-h-n]

Unnyfay, onhjay.🤠

[j-o-h-n in reply to Drphil1938]

ouyay iteyay... ectay ercay...

Good Luck, Good Health and Good Humor.

j-o-h-n Tuesday 07/30/2019 4:37 PM DST

[Karmaji in reply to j-o-h-n]

In french ...

Ass and then what (et)

[j-o-h-n in reply to Karmaji]

French Pig Latin? Onoyay....

Good Luck, Good Health and Good Humor

j-o-h-n Tuesday 09/03/2019 10:44 AM DST - Pinnes

[Magnus1964]

Why is your MO Running through so many drugs in a short time period? It does not seem like you were any of them long enough to base an opinion as to whether they were working or not.

Obviously one or more are but you may not have any of those other drugs as a fall back position. I would question your MO.

[Drphil1938 in reply to Magnus1964]

I am not qualified to question his reasoning, his goal to quote: "we want to put this stuff to sleep as quick as we can and then try to keep it there." This approach is exactly what I want, so I won't argue with him.

[tango65 in reply to Drphil1938]

The standard of care for hormone sensitive PC is ADT plus Zytiga and prednisone or ADT plus chemo. They give Casodex for 2 weeks to control the testosterone surge caused by Lupron . After the testosterone surge, Lupron will cause inhibition of testosterone production by the testis .

You had an excellent response to treatment. Congratulations. Best of luck with your journey.

[Drphil1938 in reply to tango65]

The course of treatment you describe is exactly what my MO followed, so I am not sure where Magnus was coming from.

[Magnus1964 in reply to Drphil1938]

I don't want anyone to lose confidence in their doctors. It just seems that having a patient change three different drugs in as many months is not enough time on any of any of them to make a judgment on the efficacy of any of them. Unless this is a new protocol I don't know about.

[Drphil1938 in reply to Magnus1964]

I started on Cosadex for two weeks, then a 3 mos lupron injection, 30days later PSA dropped to 18. We stopped cosadex and went to xytiga with predisone, we are now SOC .with results I gave earlier. I understand what you are saying. That we may be burning some bridges early in treatment but I am fine with where we are. I am coming up on 81 and these are bonus years. I dont want to leave any on the table.🤠

[Grumpyswife in reply to Magnus1964]

Everyone should read your amazing history. you’ve Squeezed every bit of life from each treatment. Maybe it’s different when you start at age 81 but watch out for side effects.

[Drphil1938 in reply to Grumpyswife]

Side effects have been minimal, some fatigue and five or six good hot flashes each day. Also a good martini 4 or 5 times per week keeps me relaxed and loving life.🤠

[Muffin2019 in reply to Drphil1938]

I have 10-13a day on lupron but at least I am alive and enjoying life.

[RayF in reply to Muffin2019]

I had them about once per hour, sweating like crazy, but they have become less frequent and less intense, I even wake up with a dry t-shirt some days.

[GoBucks in reply to Magnus1964]

Try looking up the Stampede trial. Thanks to those in that trial I am now 18 months <0.01 having started with 3 positive nodes and multiple bone mets. There is no "wait til later" treatment. We hit hard now and hope it works. If/when it doesn't, thankfully there are new things to try then.

[Gearhead]

Drphil: My starting point (i.e., mets, PSA, Gleason) was similar to yours, my medications sequence is the same, my rate of PSA decrease is similar, and my side effects are also minimal. Our main difference is that for me, a glass of good cabernet 6 or 7 times per week is what helps keep me relaxed and loving life.

[Drphil1938 in reply to Gearhead]

Each to his own, cheers!!🤠

[Bebby1]

Great news

Keep on living

[Lettuce231]

Fantastic news, we are all with you.

[lincolnj8]

I'm on the same meds as you are for about 20 months now. Meds in lymph nodes, bones and spots on organs. Psa was at 800 now is under .1 getting a Lupron shot every three months too. Also no pain. So glad for you that your treatments seem to be working too. Hang in there

[Drphil1938 in reply to lincolnj8]

You too, thanks for your and everyone else's encouragement. Keeps me smiling. 🤠

[lincolnj8 in reply to Drphil1938]

Sometimes I cheat and have a nice bowl of chocolate chip ice cream. Oh the simple things that make us happy

[larry_dammit]

Sounds great , never give up. Fight that monster 🙏

[Hidden]

Welcome to the survivors club Keep up the good fight!!!

[Balsam01]

With a Gleason 9, should you have genomic testing?

[Drphil1938 in reply to Balsam01]

I don't know, something to discuss with MO.

[dadzone43]

Hooray! Celebrate!

[Drphil1938 in reply to dadzone43]

I have been.🤪

[Greatfaith]

That's great news! Hang in there brother! Sounds better than having chemo. My situation is very much the same, found out in April that I have stage 4 and mets. Just had my 4th chemo infusion two days ago. My PSA is down too, and I'm feeling food about life. Thanks for sharing. Always great to hear positive outcomes.

[grahaminator63]

J-O-H-N told you to say that...didn't he?

Keep on fighting, friend!

[Drphil1938 in reply to grahaminator63]

John is my idol, I just wish he knew how to write his name. 🤠

[j-o-h-n in reply to grahaminator63]

I did...

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 07/24/2019 8:23 PM DST

[monte1111]

Looks like things are going great. I'm sure that was Good Humor ice cream you were referring to. Chocolate Chip (2 scoops). Enjoy.

[j-o-h-n in reply to monte1111]

Did you know that: Timothy McVeigh

Requested two pints of mint chocolate chip ice cream for his last meal. McVeigh chose William Ernest Henley's poem "Invictus" as his final statement. Just before the execution, when he was asked if he had a final statement, he declined.

Mint? What a sissy....

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 07/24/2019 8:33 PM DST

[gamemaster34]

Congratulation!!! I am 20 years younger and I am on the same treatment. Stay positive and enjoy each day.

[Drphil1938 in reply to gamemaster34]

The best to you also

[j-o-h-n]

Wonderful news.... I figure you'll make it to 95 1/2...

Thank you for the plug!!!

Watch for me on TV I'm going to be on Naked and Very Afraid....

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 07/24/2019 8:22 PM DST

[Drphil1938 in reply to j-o-h-n]

I may not be able to tell if you are the man or woman, due to our meds but I will be rooting for you.

[j-o-h-n in reply to Drphil1938]

I'll be the one with the exposed and bigger breasts.... Those meds do wonders...

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 07/24/2019 8:41 PM DST