At .15, an axumin scan is not going to show anything--needs to be above 1...I would wait and get the Ga68 PSMA scan when it gets above .2 and that may show where the issue is and treat it...How long off ADT?? The closest PSMA scan may be at Johns Hopkins--you could look for clinical trials and try to enroll....
As stated below in my second response, talk to an RO, look at the information I posted there...I went with the information you posted.....Sorry to hear about the climbing values....Good luck...and thanking your husband for his service...Take care...
On a per-patient basis, 18Ffluciclovine PET sensitivity for detecting recurrent disease varies with PSA values, with reported
Downloaded from jnm.snmjournals.org by on July 17, 2019. For personal use only.7
detection rates in the post-prostatectomy biochemical failure setting of 72.0%, 83.3%, and 100%
at PSA levels < 1, 1–2, and ≥2 ng/ml respectively (24). A mixed post-prostatectomy and nonprostatectomy cohort demonstrated a 18F-fluciclovine detection rate of 37.5% at PSA < 1,
77.8% at PSA 1-2, and 91.7% at PSA > 2, and 83.3% at PSA > 5 ng/ml (25). Additional studies
have found 18F-fluciclovine detection rates ranging from 21%-38.7% at PSA values of <1 ng/mL
My Mayo M.O. held off on authorizing the Axumin scan until my PSA went from undetectable to 0.22. Insurance is covering it (Medicare + Blue Cross), and it ain’t cheap. Strangely, my single bone tumor has remained “resolved,” but the scan did show some minor uptake in the left seminal vesicle, which we are monitoring. Follow Tall Allen’s link for finding the nearest location.
Google it and you’ll find a list of providers across the country and if he’s on Medicare ask if the facility has gotten Medicare approval. Wait until psa is 2.0 for the best results. Axumin is not the most sensitive but it’s the most available. PSMA ga 68 is more sensitive but it is not fda approved and is available in clinical trials only.
Since you’re looking for salvage radiation after failed RP don’t wait for Psa to rise! Just do it and radiate all pelvic lymph nodes as well. But find an excellent RO who does lots of prostates!
How many grays were administered? I had 70 grays . Now that I understand his treatments here’s my take: I too waited till Psa was above 1.2 (after having all pelvic lymph nodes done with IMRT) before having axumin scan and it found a femur met which I hit with SBRT and went back on ADT3 for 13 months. If psa takes a long time to double it’s a good sign. Mine doubled in two months. So some form of ADT is necessary because there are millions of occult cells you can’t see. The use of SBRT to radiate oligomets is controversial in that it’s not been proven to extend survival.
My view has been that if there are few visible mets blast them with SBRT which is high dose radiation requiring usually only three sessions of 10 grays each. I switched to estradiol patches instead of going back on Lupron .
Axumin is FDA approved and relatively easy to get vs PSMA which is NOT FDA approved and is done as research in the USA. Most research facilities who do PSMA studies (research studies) require a rising PSA that is at least 1.0 and often 2.0. Interestingly, these scans are already offered diagnostically in both Germany and Australia and likely other countries. Part of the USA's ongoing, most expensive, sub-par health care system. Axumin is likely the best USA test available given the present PSA .... and is likely to be negative at the present PSA. The following research article compares PSMA, C-11 Choline and Fluciclovine (aka Axumin):
Prostate cancer–specific PET radiotracers: A review on the clinical utility in recurrent disease
In this research review article there is a map of where the C-11 Choline and PSMA studies are performed ... at least at the time of the writing of the Review ... this was published in a Jan-Feb 2018 Journal.
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