CTT 1057, GA-PSMA-11, CTT 1403 --anyone heard of any of these?

[Caring7]

Husband is looking at a Stage I trial of CTT1403, which is apparently related to the first two listed. UCSF is running 1/2 the study. It's a Lutetium drug.

[tango65]

clinicaltrials.gov/ct2/show...

"Detailed Description:

This is a Phase 1, first-in-human dose escalation/dose expansion study evaluating escalating doses of CTT1403 in patients with PSMA-avid mCRPC with progressive disease on at least one androgen signaling inhibitor, followed by a dose expansion to further evaluate the safety, tolerability, efficacy and biological activity of CTT1403. CTT1403 is a PSMA-targeted 177Lu-labeled radiotherapy being developed for prostate cancer with a unique PSMA binding scaffold and an albumin binding moiety to extend circulation half-life. The PSMA binding scaffold is shared with CTT1057, a PSMA-specific PET diagnostic imaging agent shown in Phase 1 clinical trials to be specifically taken up by PSMA+ tumor. PSMA PET imaging by CTT1057 or 68Ga-PSMA-11 will be used diagnostically to select patients with PSMA-avid disease for treatment. The purpose of this study is to identify the dose limiting toxicity and recommended phase 2 dose of CTT1403. Eligible participants with demonstrated therapeutic benefit will be offered a second dose of study drug."

businesswire.com/news/home/...

Best of luck.

[Tall_Allen]

Let us know how it goes.

[Caring7 in reply to Tall_Allen]

Unfortunately -- not well. My husband was disqualified from receiving the 2nd dose because he seems to be showing progression, esp. with a growing liver met. Sigh. Seems unclear how effective LU177 is with the visceral mets (at least this version of LU177).

On to Jevtana as soon as we can, and a modified TURP because he can barely urinate. With two failed chemo attempts (Taxotere and Carboplatin) while waiting for the trial (Jevtana was exclusionary) - he's gone almost 6 months with no effective treatment (other than Lupron).

The good news is that he is home and the running around and finding places to stay is done. The clinical trial process itself was also pretty stressful. It was very . . . clinical (pretty much treated as a human lab rat -- just focusing on his results, not him), and not very caring. So we're kind of happy to be done with that too. We did get connected with an excellent palliative care doctor at UCSF -- Paul Lindenfeld, who was not with the study but works in the Cancer Center there. He was a great antidote. To be fair, Dr. Aggarwal has also been very responsive but he doesn't do much with the day-to-day. It is the "team" that does all of the coordination and check-ups that was rather indifferent (not mean but just focused on their thing and not paying a lot of attention to the fact that their "thing" involves a human being facing the last options of cancer treatment).

Despite this, hubby is doing OK and we're working on the next steps and will enjoy the holidays.

[Tall_Allen in reply to Caring7]

I'm sorry that therapy didn't work for him - yes, clinical trials do a lot of extra poking and prodding just to collect data. Even if he didn't get the second dose, his participation helped many other people (learning in whom a therapy does not work is important too). Good luck with the jevtana.

[Caring7 in reply to Tall_Allen]

Thanks. We don't really regret doing the clinical trial and he certainly benefited from men who did CHAARTED and other studies. It was just a lot more stressful than anticipated.

Yes, here's to Jevtana!!

[CantChoose]

m.jnm.snmjournals.org/conte...

Everyone is looking for that radioactive magic bullet. I hope this is the one.

[Fairwind]

So they keep increasing the dose until they get a "negative outcome" (worst case) or best case, they cure your cancer..What a crap-shoot...Good Luck !

[cesanon]

What are the expected pros & cons with respect to other psma treatments?

[j-o-h-n in reply to cesanon]

As per your request: "stop reading my posts please. Thanks" I did not read your post.

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 07/10/2019 8:14 PM DST

[TEBozo]

Had the sensitive Gallium PSMA PET scan at UCLA in March and revealed 3 lymph nodes affected post OP-Jan 4th. ADT and IMRT in process. I paid for Gallium PSMA PET

[Hidden in reply to TEBozo]

Hi, how much did it cost if I might ask? I am thinking of getting one too. Do you think there's any reason to get one if my PSA is undetectable following ADT, orchiectomy, and SABR?

[TEBozo in reply to Hidden]

$2700

[Hidden]

Hey, thanks for that guidance. I guess my oncologist will be ordering a scan when it starts it's way up, but who knows when? If it's "on time" per the curves, that will be in about 8 months.

[marykg46 in reply to Hidden]

What is the curve you mention? Is there a weblink to it?

[Hidden in reply to marykg46]

I have been in a darker mood lately, and was refering to what I have estimated as to when I will start to progress to castrate resistant, based on my overall research, and my cancer spread at dx. I could be wrong, but I figured the average time to progression is about 18 months, when on ADT(orchiectomy for me) and zytiga.

[monte1111 in reply to Hidden]

I see averages tossed about a lot. Zytiga and Xtandi a little new for real world averages? And every man's prostate cancer is different. Aren't we special. 2 years 4 mo. in. 23 mo. Xtandi. PSA 0.1 CT and bone scans Tuesday show no progression. No new mets. (But I've got a lot of other screwed up minor things. All age related.) Going to the next BBQ. Enjoy.

[marykg46 in reply to Hidden]

Oh I get it. No real curve just a calculation that you work out somehow. My husband is just about to have his second Lupron injection and in a few weeks his next PSA so that will give us some better information as to where things are at...

[Hidden in reply to marykg46]

Yes, sorry to have posted like I did.... the 18 months. So, today in a much better mood, and I am feeling positive about living well with the time I have left. Hey, is your husband also on zytiga?

[marykg46 in reply to Hidden]

No need for an apology I didn't read it as negative just a statement of how things are. Nope he's just on Lupron and it took quite a bit of doing before the specialist put him on that. Specialist appointment on August 1 and as it's been a downward spiral since day one we don't really go expecting any good news...maybe that's a glass half full approach but then we can brace ourselves for what comes next. I was going to write to fish on this site to ask what will come next if his PSA has gone up significantly as he always seems to have the right advice. I guess it zytiga from what I read. We had asked if he could have 177Lu but his specialist said that was just for men with much more widespread metastasis. Hope you're feeling more positive.

[middlejoel]

Nal in your reply you say that you would wait until PSA rose above 0.2 before testing with Gallium PSMA , do you mean 2.0? In your opinion, what is the lower level that begins to provide accurate readings?

jal