Started trial today

[beatPC]

So my ANC is good today and I’ve started CPI-1205 trial. Wish me luck.

[Tall_Allen]

I hope it works! Keep us informed.

[beatPC in reply to Tall_Allen]

Thanks. Will keep all informed.

[CantChoose]

Very best of luck!

And I'll leave this here so others don't have to look it up:

ascopubs.org/doi/abs/10.120...

ProSTAR: A phase Ib/II study of CPI-1205

Background: EZH2 is frequently mutated and/or overexpressed in numerous cancers. High EZH2 expression is correlated with poor outcomes in prostate cancer patients (Varambally, 2002). EZH2 inhibition combines synergistically with anti-androgen therapies in preclinical models of advanced prostate cancer, suggesting epigenetic reprogramming as a pathophysiologic mechanism to enhance the combination therapy (Ku, 2017; Xiao 2018; Constellation, unpublished). CPI-1205 is a potent, selective, and cofactor-competitive inhibitor of wild type and mutant EZH2 catalytic activity, which demonstrates anti-proliferative effects in prostate and other cancer cell models.

[beatPC in reply to CantChoose]

Thanks & thanks.

[farmanerd]

enter a trial

to remove tribulation

please let it be so

Best wishes beatPC,

- Mark

[beatPC in reply to farmanerd]

Thanks.

[NPfisherman]

Congratulations....glad you made the trial and hope it sends your PCa cells into oblivion...Best of luck...

Fish

[beatPC in reply to NPfisherman]

Many thanks.

[tango65]

Best of luck.

[beatPC in reply to tango65]

Thank you.

[Peterd110]

Good luck!!!!

[beatPC in reply to Peterd110]

Thanks

[Schwah]

Big fan base over here. Can’t wait to hear your good news.

Schwah

[beatPC in reply to Schwah]

Thanks. I’ll try to keep the news good.

[Molman]

Hi Beat, wishing you luck. We all need a little of that.

[beatPC in reply to Molman]

Thank you

[deedeer]

Wishing you the very best of luck

[beatPC in reply to deedeer]

Thank you

[Trecento]

All the best, hope it goes really well for you.

[beatPC in reply to Trecento]

Thank you

[JuanVV]

Best of luck!!

[beatPC in reply to JuanVV]

Thanks

[dadzone43]

Bon chance

[beatPC in reply to dadzone43]

Merci

[larry_dammit]

Good luck 👍

[beatPC in reply to larry_dammit]

🙏🏿

[ronnie1943]

Good Luck!!! Let us know how you make out...

[beatPC in reply to ronnie1943]

Thanks. Will do

[Bebby1]

Good luck

Go hard 👍👍

[beatPC in reply to Bebby1]

OK

[tkalaf]

We wish you the Very Best in this Trial!

[beatPC in reply to tkalaf]

Thank you

[Rick-s]

Hope things go well will keep you in our prayers

[beatPC in reply to Rick-s]

Thank you

[SeosamhM]

Go get 'em, Beat!

[beatPC in reply to SeosamhM]

Thanks

[Bob10]

Good luck

[beatPC in reply to Bob10]

Thanks

[Bob10 in reply to beatPC]

Beat Why did u pick this Trial

[beatPC in reply to Bob10]

at the suggestion of my onco. enzalutamide is no longer effective and my condition is a bit premature for “hard” chemo so i’ve been switch to abiraterone with cp-1205 which is designed to help the immune system

we shall see

[Hohman]

Best of Luck!!....please keep us updated!

[beatPC in reply to Hohman]

Thanks will do. So far the fatigue is phenomenal. Nausea is very pronounced bit but i’ve managed to keep everything down. bad diarrhea yesterday, but no abdominal pain associated with it. a little unsteady on my feet. i hope my body gets accustomed to the symptoms and is able to tolerate them better or mitigate them to some degree.

[beatPC in reply to beatPC]

Found that waiting an extra 30-60 minutes more than the recommended 1 hr after taking CPI-1205 before eating eliminates diarrhea problems.

[monte1111]

You got a heck of a fan base! I'll add my good luck here.

[beatPC in reply to monte1111]

thanks. this is quite a crew! really grateful for you all

[j-o-h-n]

Hey beatPC, Do you know the difference between an egg, your wife and a B. J.?

Well, you can beat an egg, you can beat your wife but you can't beat a B. J.

Hopefully you'll beatPC with the trial.... keep us posted, please....

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 06/13/2019 5:22 PM DST

[beatPC in reply to j-o-h-n]

Good humor is crucial