Zytiga is slowlyletting us down

[Olivia007]

Zytiga looks like it’s skowly stopped working, my dad was on it for a good year and a half his PSA is slowly rising last month it was .46 this month .68 I don’t know what the doctor will suggest we do. This is scary and exhausting keep trying something else to fight this devil (cancer).

He is in lupron injections and had provange done but I’m wondering what else will the doctor offer.? Any thoughts or suggestions I know it worked for you I’m just trying to see what else we have to look forward to.

Thank you, Olivia

[Magnus1964]

There are other ADT drugs that can be prescribed. They all work in different ways. He could try casodex, zytiga, etc.

[NPfisherman]

If you want to squeeze a little more out of zytiga--get his numbers lower---there are a couple of options---adding indomethacin, and/or--switching from prednisone to dexamethasone...

ncbi.nlm.nih.gov/pubmed/277...

and the dexamethasone article:

ncbi.nlm.nih.gov/pubmed/300...

Get the max out of zytiga before moving on....

All the best,

Don Pescado

[Tall_Allen]

He can try switching from prednisone to dexamethasone. In the following study, more than half the men remained sensitive to Zytiga after the switch:

onlinelibrary.wiley.com/doi...

After Zytiga stops working, Xtandi may work at least for a while.

If he has bone mets, Xofigo would be a good next choice. Docetaxel is good for any kind of metastasis. If he is taking a bone strengthening agent (Zometa or Xgeva), adding Celebrex to it has been shown to increase survival by 22%.

There are many more drugs in clinical trials.

[Mkeman in reply to Tall_Allen]

TA...do you have the link for the Celebrex study. My MO hadn’t heard about it. Thx

[Tall_Allen in reply to Mkeman]

ascopubs.org/doi/10.1200/JC...

[Mkeman in reply to Tall_Allen]

Thanks!

[Bebby1 in reply to Tall_Allen]

What about Monica as an anti inflammatory adjuvant

Does anybody have any thoughts

[Tall_Allen in reply to Bebby1]

Monica?

[Bebby1 in reply to Tall_Allen]

Meant mobic..... sorry no glasses

[Tall_Allen in reply to Bebby1]

I don't know - they only tested the combination of Celebrex and Zometa.

[Bebby1 in reply to Tall_Allen]

Thanks

I’m in Australia

Drugs names are different but seems you guys have a lot more options

If enzalutamide doesn’t hold him we will be eligible for US trial

Thanks again

[Tall_Allen in reply to Bebby1]

The generic names of those drugs are celecoxib and zoledronic acid.

[Cgjunior in reply to Tall_Allen]

Hi TA, would u have a link to the Celebrex study? I would like to print it and bring it up w my MO. Thanks!

CG

[Cgjunior in reply to Cgjunior]

Sorry, just read further and saw the link

Thnx

[Olivia007]

Thank you

[Olivia007]

Yes he has bone Mets and gets his monthly xgeva we will keep trying

[Kevinski65]

Zyflamend whole body helps but you better get scans to go with it.

[charlesmeyers1964]

zytiga isn't meant to last forever just temporary. psa of .46 where the normal male has a psa 0f 0-4.0, i wouldn't get to excited on this

charlie

[Olivia007 in reply to charlesmeyers1964]

Ask it was .46 now it’s .68 and I’m not excited its the doctor that was alarmed so I got alarmed.

[charlesmeyers1964 in reply to Olivia007]

read up on mets or whatever they call the problem (cancer) if he has been treated or not? how long the battle with it? stage 4 usually means the cancer has spread sooooooo it depends on the numbers or where it has spread, or what treatments to cutain the spreading. lots of ?s

charlie

[dadzone43]

consider metformin

[Olivia007 in reply to dadzone43]

He is on metformin for his diabetes and has been for years should we increase the dosage?

[charlesmeyers1964 in reply to Olivia007]

metforium is diabetics not prostrate cancer. what is your doc a general, oncologist, or urologist?

charlie

[Olivia007 in reply to charlesmeyers1964]

He’s a urologist I don’t know why anyone is recommending metamorfin when it’s used for diabetes and like I said my dads been on it for a while and hasn’t really done anything for his PSA and most Doctora treating him for this cancer really don’t believe anything works only what they r taught in school or by their peers they only want to do conventional approaches

[charlesmeyers1964 in reply to Olivia007]

zytiga workes for prostrate cancer, metforium is for diabetics patents only. i found a better urologist then my oncologist doctor. remember u can get a second opinion. u can ask the doc why is he on metorium instead of zytiga???

charlie

[dadzone43]

What dose metformin?

Is he taking POMI-T?

[Olivia007 in reply to dadzone43]

What is Pom-t

[FenBenGolf]

Looks like I had a similar regimen. Chemo (docataxel) plus Lupron. That was good for about 2 years (that is what they predicted). Continued Lupron and added abiraterone (Zytiga) which they indicated was good for around a year. Sounds like you got more than a year out of it. Dr. said they have other options after this stops but didn't say what since there are new drugs and studies coming out. I keep kicking the can down the road but the road is narrowing!!