Primary treatment of locally or regionally advanced prostate cancer (PCa) with radical prostatectomy and adjuvant radiotherapy is associated with a lower risk of cancer-specific death and improved overall survival compared with primary treatment consisting of radiotherapy plus androgen deprivation therapy (ADT), new study findings suggest.
Surgery + Radiation for Advanced PCa ... - Advanced Prostate...
Surgery + Radiation for Advanced PCa Offers Better Survival than RT + xRT
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George71
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Very poor study. Most people who post studies on this site haven't a clue as to how to evaluate them. Here's how their peers responded (peer response is important in such journals). Patients should be wary of posts of research without commentary evaluating it and its context. Database analyses are often just a cheap and easy way for an academic to get published. They are notoriously plagued by selection bias. Here's a response to a similar database analysis:
"We read with interest the National Cancer Data Base (NCDB)
study by Berg et al. [1] comparing overall survival (OS)
between men aged 65 yr with high-risk prostate cancer
(PC) receiving radical prostatectomy (RP) and those receiving
external beam radiotherapy with a brachytherapy boost
(EBRT + BT). The authors conclude that EBRT + BT was
associated with significantly worse OS, with a hazard ratio
of 1.22 for all-cause mortality. When considering the validity
of this conclusion, three salient points must be considered.
First, cancer registries inherently cannot capture the
selection bias that affects treatment allocation to RP or
EBRT + BT, even among “healthy” patients. For example,
several different registry studies have shown implausible
OS differences among patients with low- and intermediate-
risk disease, with divergence of survival curves for RP and
EBRT—favoring RP—within 3 yr post-treatment, in stark
contrast to the level 1 evidence provided by the ProtecT
trial, which found no differences in all-cause mortality at
median follow-up of 10 yr [2,3].
Second, the dominant cause of death even in high-risk PC
is other-cause mortality [4]. The NCDB provides no
information on tumor control specifically, and one cannot
correct for unmeasured confounding variables that would
favor improved other-cause mortality in RP patients.
Therefore, any difference identified in OS is most likely
attributed simply to differences in other-cause mortality.
Third, the authors state that they did not account for the
use of androgen deprivation therapy (ADT) in the treatment
groups. Both the European Association of Urology/European
Society for Radiotherapy and Oncology/International Society
of Geriatric Oncology and National Comprehensive Cancer
Network guidelines recommend long-term ADT with EBRT
+ BT, reflecting the multiple randomized trials that have
demonstrated a robust OS benefit for use of long-term ADT
with EBRT. No high-level evidence exists to suggests that ADT
can be foregone with EBRT + BT, and hence all professional
societies consider it to be the standard of care to use ADT of
sufficient duration with EBRT + BT. Thus, the inclusion of
patients not receiving ADT (31% of EBRT + BT patients) and
the inability to account for ADT duration in this analysis are
troubling. This is evident if the results are contextualized
with two other studies with biopsy Gleason score 9–10
disease. The first found a PC-specific mortality benefit for
EBRT + BT (with median ADT duration of 12 mo) over RP
[5]. The second found an OS benefit for EBRT + BT (with
median ADT duration of 6 mo) overRP without postoperative
therapy, and equivalent OS between EBRT + BT and RP with
adjuvant EBRT [6].
Given the inherent differences between patients who receive RP and those who receive EBRT + BT, we acknowledge that all retrospective analyses are intrinsically
an “apples to oranges” comparison. However, in any such
comparison, it is even more imperative to enrich for explicitly
codified standard-of-care treatments.
Ultimately, the superiority or noninferiority of RP versus
EBRT + BT needs to be determined in a prospective,
randomized fashion. We would be highly supportive of a
clinical trial to help answer this question for the thousands
of patients diagnosed with high-risk disease annually.
References
[1] Berg S, Cole AP, Krimphove MJ, et al. Comparative effectiveness of
radical prostatectomy versus external beam radiation therapy plus
brachytherapy in patients with high-risk localized prostate cancer.
Eur Urol. In press. doi.org/10.1016/j.eururo.20...
[2] Pearlstein KA, Basak R, Chen RC. Comparative effectiveness of
prostate cancer treatment options: limitations of retrospective
analysis of cancer registry data. Int J Radiat Oncol Biol Phys. In
press. doi.org/10.1016/j.ijrobp.20...
[3] Hamdy FC, Donovan JL, Lane JA, et al. 10-Year outcomes after
monitoring, surgery, or radiotherapy for localized prostate cancer.
N Engl J Med 2016;375:1415–24.
[4] Johnston TJ, Shaw GL, Lamb AD, et al. Mortality among men with
advanced prostate cancer excluded from the ProtecT trial. Eur Urol
2017;71:381–8.
[5] Kishan AU, Cook RR, Ciezki JP, et al. Radical prostatectomy, external
beam radiotherapy, or external beam radiotherapy with brachy-
therapy boost and disease progression and mortality in patients
with Gleason score 9–10 prostate cancer. JAMA 2018;319:896–905.
[6] Tilki D, Chen M, Wu J, et al. Surgery vs radiotherapy in the manage-
ment of biopsy Gleason score 9–10 prostate cancer and the risk of
mortality. JAMA Oncol. In press. doi.org/10.1001/jamaoncol.2018.4836.
Amar U. Kishan
William A. Hall
Daniel E. Spratt
europeanurology.com/article...
I welcome what others post that they find in their research that they think may be of interest to the community -- All here are grown men with the ability to read and decide for themselves -- I value the opinion of the persons who do these studies over yours TA.
If someone finds an article written by clinicians or doctors I hope they will post it for all to evaluate for themselves and not wait for you to approve or let you censor this forum.
The people that conducted the study and published their findings are much more qualified anyone on this forum -- I would trust their judgment over yours since you are not a doctor or qualified to treat anyone.
as opposed to the authors of the study :
Thomas L. Jang MD, MPH
Neal Patel MD
Izak Faiena MD
Kushan D. Radadia MD
Dirk F. Moore PhD
Sammy E. Elsamra MD
Eric A. Singer MD, MA
Mark N. Stein MD
James A. Eastham MD
Peter T. Scardino MD
Yong Lin PhD
Isaac Y. Kim MD, PhD
Grace L. Lu‐Yao PhD, MPH
.
There are reasons why one kind of evidence is better than another. Some people post mouse studies and claim they are as good as large randomized clinical trials. People can decide for themselves if this understanding is provided. Those who neglect to do so may be misleading others. I have spent 20 years in research and understand how to evaluate studies. I hope you will take the time to learn.
The authors of that article also wrote "The investigators stated that their findings should be interpreted within the limitations of an observational study design. “Because our patients were not randomized, the 2 treatment groups may have differed in measured and unmeasured ways that are associated with differences in survival despite our best efforts to rigorously adjust for confounders,” they noted."
They understood the limitations of the study and the conclusions to be drawn from it in a way you apparently do not. Since you trust the authors, you should trust them on this too.
Most of us here are simply sharing our treatment plans, results, doctor recommendations and latest research, studies, trials etc. etc. solely for the benefit of the community and for each of us to read (or not) and decide for our self.
On the other hand - some appear to have a broader agenda – to use the forum to represent their self as an authority and to enhance their own stature. The process is to (1) find any reason to criticize virtually every post making him look like the authority over (in this case) 13 doctors (2)and then reference an article he wrote on his website to get everyone go over there instead.
If I wanted to go to his website I would .. his website will never be an open forum like this is intended to be-- because obviously, there is no room for any views other than his. He is high jacking Healthunlocked as if it is his website.
People here are looking for more than TA's opinion – otherwise they would go to TA’s website where you won’t be able to speak openly since TA won’t allow it here either.
If TA is allowed to censure everyone here – and talk down to them -- soon people will find other alternative sources to share ideas and communicate at. Healthunlocked is being used by TA to enhance himself – TA is not a doctor or qualified to treat anyone.
The 13 doctors should have checked with TA prior to doing the study so he could tell them they are wasting their time.
Some people who post hide the important parts. I can't say if the intention is to mislead or it is out of ignorance. I assume the latter, and have tried to educate you - which you seem to resent.
As I said-- (1)You post links to your own site to articles you wrote that are shaped to fit your opinion. (2) You are not a doctor or able to treat anyone (3) while criticizing articles written by 13 people who actually ARE doctors -- and (4) direct others from here to your website regularly.
And, as I said -- The 13 doctors should have checked with TA prior to doing the study so he could tell them they are wasting their time.
Unlike you -- I didn't rewrite the article - I posted the link to the actual article for everyone to read for themselves rather than have you interpret it for them.
• in reply toGeorge71
Let’s ask T_A if he’s a paid advocate . By Hu or big pharma..
Tall_Allen• in reply to
No, I get no pay for this.
• in reply toTall_Allen
Then I commend you for helping others..
• in reply toTall_Allen
Although we differ on many things, I hope that I can call on you if I need your help.. Surley no is here to create bad blood or enemies. Peace you T_ A .
• in reply toTall_Allen
As much time as you put in . You should be paid...
TA
What are the “inherent differences” between men receiving RP and SRT vs. RT , BT and ADT?
I didn’t realize there was a clear cut difference in N0M0 patients and I thought that either tx was a viable option.
Bob
Men suitable for surgery tend to be younger (10 years on the average), healthier, and have fewer known comorbidities. Because of this, there is an inherent bias in favor of surgery on survival. For example, expected 10-year survival for a healthy 60 year-old man is much better than for a 70-year-old man with, say, COPA. Multivariate statistics can only partially correct when the variables (like age) are given - they can't correct for unmeasured variables or when there is not significant overlap. Database analyses have inherent data limitations (they collect only certain data about patients), so they cannot be used to decide between the effectiveness of therapies.
I agree re: younger men and healthier men are more amenable to RP . The study did at least say all men were 65 or older.
Like so many . Surgery wasn’t an option for me... Adt & RT have worked so far.. if you are a candidate for RP , by all means go for it...
• in reply to
In my case qualifying for surgery was fairly stringent: under 60, BMI under 25, fit, and good odds of success. With all that and a perfect pathology report, except bumping from G8 to G9, my PSAnever went undetectable, and I was bcr I three months. That said was it worth it? I dunno. I figure I had to give it a shot, since a “cure” was at least possible, though not likely. Owed my family that, I guess.i’d do Anything for them.
Break60• in reply to
Interesting. I guess the prerequisites for RP at Johns Hopkins weren’t as stringent: age 69, BMI around 30, otherwise healthy but Gleason 9. I have total ED and very minor incontinence but thankfully low volume bone mets.
• in reply to
No guessing. You will .
Let’s not demean ta. He is extremely resourceful and analytical. Rutgers??
• in reply toHirsch
True , unless you differ of opinion . Then expect to be put down..
U of Rochester undergrad - Columbia U grad school
• in reply toTall_Allen
Fantastic !
• in reply toTall_Allen
Nice to meet you . I’m an eighth grade drop out . But at least I Was taught how to be kind and respect others opinions and viewpoints.. and if I don’t , I try my best to hold my tongue. Thanks for doing all of your research into Pc. But talking about APC , especially #4 , is different then living with it. Nobody with APC need s to be put down or belittled , especially , harshly by someone that doesn’t. If you had it you would know this.
Tall_Allen• in reply to
I suppose you would say the same about Darryl or the hundreds of researchers, caregivers and patient advocates who devote themselves to helping people with prostate cancer. if you don't want to further your reputation as a troll, you should share comments like that only privately or keep them to yourself, because I'm not interested, nor, I assure you, are the many caregivers who you are insulting.
• in reply toTall_Allen
You suppose much ..that’s not scientific . I see no one except you doing the insulting . Whom have I insulted? I apologize. Not my intent . Can you say that you don’t know that you insult not just a few but many? Troll , voodoo , is that all you’ve got. Talk about insults.. “ when the debate is over , slander becomes the tool to the loser” slander is your forte..
Hahahaha
Darryl is doing just fine. I hope that such postings do not go unchallenged. Many might be misled by misleading posts.
• in reply toTall_Allen
All I know is that I know nothing...I’ll leave it to the more superior minds than my own , to understand the convoluted life with APC.. Everyone is fighting a hard battle so a little kindness to those that are uninformed or to those that offer different viewpoints than yours would create peace on HU. No one deserves to be put down. Things like “ Vegan smeagan “ belittle others beliefs. I believe that you yourself said “” Alternative medicine is more of a religion than science. “ Then why insult another’s religion. “.? You’re better than that T_A.....
Tall_Allen• in reply to
Religion is no way to treat prostate cancer. You may advocate voodoo or naturopathy or whatever, but that may get in the way of the survival of others. What you do to yourself is your business, but when you publicly advocate it, you are inviting response. "Vegan Shmegan" was my humorous title for a post about a randomized clinical trial that found no benefit to increasing vegetable intake.
• in reply toTall_Allen
Humorus to you..
• in reply toTall_Allen
I don’t profess to be an advocate. I tell people what I’ve done... no benefit to veggies is pure .. idiocy
Tall_Allen• in reply to
"I don’t profess to be an advocate. I tell people what I’ve done... no benefit to veggies is pure .. idiocy" You do see the irony in that post?
• in reply toTall_Allen
No , but you do , and that’s all that matters . Your bio starts off first thing “ Advocate” To me it seems like HU is a place for you to establish your dominance in intellectual prowess .. But when insults start you lose that battle. Kindness and compassion are also treatments for APC. No double blind clinical proof of that either. But 99 % of us living with APC understand that.. a kind approach helps the medicine go down . Not to just those that agree with you on everything.
Tall_Allen• in reply to
It's ironic because you contradict yourself by first claiming not to be an advocate for your position, and then calling anyone's proof that your advocated position is invalid "idiocy." if you want to believe whatever you believe in spite of all evidence to the contrary, that is certainly your right. I hope you understand that I would still try to help you in any way I can in spite of your trollish behavior.
• in reply toTall_Allen
Thanks for that T_A ..Trolls can’t help being trolls. But thanks for the compliment.. You know so much. I grew up with a Mensa society know it all. Nobody knows it all. I’m stating what I do or have done thats it. Many of us are not here just for scientific explanations .. and not many are here to argue or to prove a point . Certainly not me. when the debate lowers to argument we should all walk away. Peace ..thanks for keeping it interesting.. take care..
• in reply toTall_Allen
My evidence is that I’m living in clear status. Not to say I’ve beaten the beast . We all know the stats, but if I believed in stats I’d be dead already .
And, I suppose, You have appointed yourself to make that determination for all the rest of us. You are just Too Much! Be Well & Stand Tall - cujoe
You are free to state your opinion as well. It's an open forum. If someone finds my arguments more convincing, that is up to them. The fact that you find it necessary to attack me rather than the content of what I post, shows everyone the bankruptcy of your argument.
Good to hear!🤕
They are good buddies.. so what.. we all need friends..
Tall_Allen• in reply to
We have met twice, briefly. I'm sure we would be good buddies if we didn't live 3000 miles apart. I would say we have mutual respect.
The doctors don't need a non doctor or anyone else to rephrase what they said -- they said what they meant, Here is what the Doctors said in THEIR words:
"Results:
From 1992 to 2009, 13,856 men (≥65 years old) were diagnosed with LAPCa or RAPCa: 6.1% received RP plus XRT, and 23.6% received XRT plus ADT. At a median follow‐up of 14.6 years, there were 2189 deaths in the cohort, of which 702 were secondary to prostate cancer. Regardless of the tumor stage or the Gleason score, the adjusted 10‐year prostate cancer–specific survival and 10‐year overall survival favored men who underwent RP plus XRT over men who underwent XRT plus ADT. However, RP plus XRT versus XRT plus ADT was associated with higher rates of erectile dysfunction (28% vs 20%; P = .0212) and urinary incontinence (49% vs 19%; P < .001).
Conclusions:
Men with LAPCa or RAPCa treated initially with RP plus XRT had a lower risk of prostate cancer–specific death and improved overall survival in comparison with those men treated with XRT plus ADT, but they experienced higher rates of erectile dysfunction and urinary incontinence."
As I said earlier:
"Unlike you -- I didn't rewrite the article - I posted the link to the actual article for everyone to read for themselves rather than have you interpret it for them."
Maybe true, maybe not, who cares anyway? My guess is that primary treatment choices are made very subjectively by each of us based on our own outlook on life and the QOL vs longevity concerns. Debate this to your heart's content, it matters hardly at all.
All the best
My doctors, who have seemingly done right by me so far, would strongly disagree. They would also say that the bulk of the credible studies on the subject would contradict that statement. I guess my point would be that such a strong assertion seems contentious at best.
On a lighter note, I just finished 35 of 35 EBRT treatments today so I'm feeling good. I'm not an expert on the studies, but I ALSO had RP just 6 months ago too, SO I'm hoping to get benefit of the big triple play....RP + RT + ADT.
Now, I just need to endure the months of ADT still ahead...
• in reply toPGDuan
Knock it out of the park.
• in reply toPGDuan
Great job escaping the easy -bake.. oven . That glow stays with us for some time. It can work .. good luck..
I was too far gone for RP or RT. Never the less, this was a very entertaining post. Monte: school of hard knocks.
Appreciate your post....as I say...take out the mothership when you can...using data from over 10,000 patients adds validity to this ....as they said, we attempted to remove any confounders with this study....I am a believe in stereotactic radiation for treatment--someone else here is not---the studies so far indicate that it works and well on OS but until double blind Phase 3, someone will not endorse it...My question is....
If his followers don't get stereotactic radiation and it proves to be of significant value, will that poster feel regret ...I doubt it...
Take out the mothership....LOL... makes me think of George Clinton... tear the roof off the mother...
youtube.com/watch?v=2DdCQ0J...
Geez I can't stop the grove... Hard to type and move....
Good Luck, Good Health and Good Humor.
j-o-h-n Friday 02/15/2019 4:20 PM EST
Almost as good as listening to Rick James...brings back memories...Thanks Brother J
For you, Brother J--just skip the ad....
youtube.com/watch?v=dWZkxYa...
Always the best to you, Mr. Stand Up Comic Relief...
Fish
Love it.... thanks...
Good Luck, Good Health and Good Humor.
j-o-h-n Friday 02/15/2019 5:09 PM EST
• in reply toNPfisherman
Best version that I’ve ever heard.. nice job. Mary Jane is a classic. This version the band sounded better than ever. Rick wasn’t disco. A god given gift fueled by Peruvian flake and sex produced some songs I loved then and even more now . I was 20 . If our hand could turn back time. I should have learned how to moon walk. I’m Rick James Bitch!
• in reply toj-o-h-n
This was around the last time that I saw live the P - funk all stars.. thanks for taking me back. GeorgeC Tears the roof off the sucker every live performance. An original . Thank you
Ok guys you want pedigree? Well here it is: Undergraduate degree from King Farouk University in Cairo, Egypt. Graduate degree from Sam Houston Institute of Technology, and doctorate from Columbia University Northern Texas. So got me a BSMSPHD = Bull Shit, More Shit, Piled High and Deep. Diplomas up the gizzou hanging in my 1985 Yugo rag top.
Just in case you missed the King Farouk University's nickname it's Farouk U.
Good Luck, Good Health and Good Humor.
j-o-h-n Friday 02/15/2019 4:35 PM EST
• in reply toj-o-h-n
What do ya call a Yugo When it breaks down? You don’t go...diplomas or not that thing is a classic now.. if it goes..?
Hail to king Farouk , aka , j-o-h-n for keeping our sinking ships afloat with intergrity and humor .
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