DNA Test recommendation

My husband did a guided biopsy (TRUS).

He has T3b N1 M1 prostate cancer Gleaston 9.

I feel a DNA test for mutations could be useful for the future treatments. What do you think and which test do you recommend?

How much do they cost and we're they useful to you?

[Hidden]

Hi Nala,

I like the service, will ask (demand) my doc to order it. Don't want to start an ideology flame war here, but in my 20+ years of software development for healthcare and clinical research, it's capitalistic opportunities that advances life!

Prostate cancer treatments are anemic, all, we have to take charge for ourselves, there was only one Dr Myers, all others are not commited, like we are to ourselves.

[Tall_Allen]

They are usually not useful and are very expensive and usually not covered. There are only 2 medications for rare conditions (carboplatin for DNA repair defects and Keytruda for MSI-Hi/dMMR) that are currently available outside of a clinical trial. There are many clinical trials for PARP inhibitors and other experimental medicines where you can get the analysis and the medications done for free.

Remember that the cancer evolves, so the genomics will change over time. So do you want to spend the money now when the genomic changes are less or wait until there are more actionable possibilities (and there will be more approved medicines over time)?

A less costly, and possibly more useful analysis (done by your hospital's pathology lab), is immunohistological staining.

Caris, Foundation One are major suppliers. Guardant360 only requires a blood test but is very expensive.

[Hidden in reply to Tall_Allen]

Your advice is noted, the "actionable" point is spot on. My interest with Foundation One, they provide a portal into your DNA sequence. They are a patient consumer service, I'm a Dana-Farber patient, signed my labs away for their interest, they use this for NIH grants and other funding sourcing, but I don't have any access to how they use my data.

This is common practice, us patients have no rights to our data...

[Hidden]

Exactly, this was why I fired my doc oncologist recently, In just a few months, my research overwhelmed my doc, folks please settle on a real prostate cancer expert.

[Hidden]

is it the FoundationOne CDx?