For women, estrogen HRT orally raises risk of blood clots, transdermal does not

[cigafred]

...A study in BMJ found that hormone replacement delivered through the skin by injection or skin patch entails no increased risk for blood clots. British researchers looked at 80,396 women who had blood clots while on various H.R.T. regimens, comparing them with 391,494 controls. After adjusting for ethnicity, smoking, alcohol use, chronic medical conditions and other factors, they found that oral preparations increased the overall risk of clots by 43 percent. Oral drugs containing equine estrogen more than doubled the risk in some regimens, although the absolute risk for blood clots is small. But skin treatments, including patches, creams, gels and under-the-skin injections, had no effect on the risk for blood clots.

nytimes.com/2019/01/09/well...

[pjoshea13]

In terms of estrogen therapies for PCa, I think that it is well-known that oral DES (diethylstilbestrol) at the high doses that were often used, substantially increased the risk of unwanted coagulation, whereas, as Richard Wassersug has pointed out, transdermal estradiol as used in the Prostate Adenocarcinoma: TransCutaneous Hormones (PATCH) trial does not have that risk.

Where low-dose estradiol is used with standard ADT for bone health, the dose itself is not a risk factor for clotting.

-Patrick

[cigafred in reply to pjoshea13]

Thank you sir.

[j-o-h-n in reply to cigafred]

Patrick is another guy who knows his shit....

Good Luck, Good Health and Good Humor.

J-o-h-n Wednesday 01/23/2019 7:24 PM EST