Had my scheduled appointment November 28 for my 6 month Lupron shot, blood work showed PSA trippled, from .03 to 1.00. Have to have one more psa test in February, to show actual jump, but sure I'm castrate resident, plan is too start progene and Zytiga treatments at that time. been 3 years since diagnosis, just wondering if timing is about right for MCRPC?
Game changer: Had my scheduled... - Advanced Prostate...
If your Gleason was 8 or higher, and an initial PSA at DX was 20+, the answer is a could be likely.
Sometimes all you may need is a blocker to the receptors like 50 mg Casodex, to knock it back down.
But First I have trouble with your numbers. If you were 0.03, and you tripled approx. you would be 0.1 not 1.0---If really 1.0 from 0.03 then when I said likely--it is likely.
At my last ADT injection, I asked my urologist how long I can expect my cancer to remain castrate sensitive. He said the average time from diagnosis until resistance develops is between 2 and 3 years. Since I had chemo right at the beginning, he is hopeful that my transition to resistance will be closer to 3 years. Good luck to you.
I’m in the same boat. At Dx I was Gleason 7 (4+3), PSA 4.65, oligometastatic with 1 tumor on my inferior pubic ramus. I have been getting treatment from Dr. Tan at the !ayo Clinic in Jax, FL. I had 3 1/2 years of blissful complacency on ADT (Lupron + bicalutamide) and a 6 cycle course of docetaxel last year. Still asymptotic (other than side effects of the ADT), no bone pain, and as of my 2 most recent PET scans, my one bone tumor failed to “light up” the PET scan. All of which I am very thankful for (yep, I ended the sentence with a preposition...mea culpa).
I got the bitch slap of reality on New Years Eve day when my PSA went up to 0.12, no longer undetectable. Not how I wanted to start the new year. Oddly, all the rest of my blood work was WNL, and testosterone remained <7. Go figure.
I go back to the Jax Mayo on 2/5 for Guardant genomic testing, a PET scan to check on any tumor activity, another PSA reading, and another visit with my MO to decide where we go from there.
And (segue) where I go from here right now is to the golf course to get 18 holes in on a beautiful central Florida day. 🏌️⛳️😎
Please keep us all posted on how your treatment goes. Best wishes to you. Have a great day! 😃
My personal preference is NO HORMONE THERAPY. I am post RRP-Da Vinci (Apr. 2014), cancer not contained in Prostate sack, non-nerve sparing. IADT with Lupron thereafter. My PSA has been climbing for the last four months (almost 10) and the Huntsman Cancer Institute in Salt Lake City re-starts ADT at 10. I've been bustin' my ass eating healthier, taking Airborne and Hemp Oil (RSO at night) and watching indulgences (sugar, beer, bourbon and red meat) as well as praying and meditating. I just called the lab and they told me it was lower on 12/31, but I would have to contact my Doc. (Agarwahl, Neeraj at HCI) for actual figure!!!!! I'LL TAKE THAT GOOD NEWS!
With my background behind me, I can say, without hesitation, I HATE ADT/Hormone Therapy and value my Family more than anything. I've about lost Family members while on Lupron (because I was an ASS) and I cannot have that. I've recently met multiple times with a great Therapist (Godsend Carla Nelson of AZ!!), and shed my anger over my dad passing away when I was 14, Mom dying when I was 28, and later, what I like to call Family Business Combat, or FBC (I am a Family Business Combat Specialist)!! Lupron was not the only thing to blame, but I won't take the chance again right now! In fact, my Therapist thought that anger and anger at others weakened my Immune System. So, get Anger Therapy if you even think it might be a small thing. You may be angry at your body. It really doesn't matter what it is, as long as you purge it.
My advice: Try God, Love, Mother Nature (MMJ), Anger Therapy and good diet FIRST. Break a leg!