My husband started on Lupron 3 months ago, and had his first infusion of Docetaxil on December 5th. He was scheduled for his 2nd infusion today, but his ALT(SGPT) numbers are too high. The progression has been from 32 to 69 to 165 to 234 today. Have any of you experienced this (either from the Lupron or Docetaxil), and if yes, what did you do?
Thanking you in advance for any advise you can share ...
It's most likely from the Docetaxel. I also had to postpone one of my chemo infusions because of high ALT. In my case, I was in the 90s and we just waited a week and it came down. It went down quite a bit in just a week. I was still outside the normal range, but we went ahead. They generally won't treat if the ALT is greater than 1.5X upper limit normal (84).
Thanks, Gregg57. Yes, with an ALT of 234, we're not sure it can come down enough. Recheck on Monday. If it's still high, he needs a liver ultrasound. This has become our 'new normal'.
I know what you mean. "Normal" is a moving target with this disease. When I start getting distraught, I find that just focusing on "what's the next step" and trying not to get too much into everything that that "might" happen down the road. Doctaxel can definitely raise the ALT, so there's a good chance it will come down by itself like mine did. Good luck, hope things work out well for him and he can get back on chemo. It really does work well for many people. It got me pain free and PSA down to .19 from 463 and opioid pain levels at diagnosis. Would definitely do it again.
How long did it take for the numbers to come down? His are going in the wrong direction.
Mine came down from somewhere in the 90s to I think just under 80 in around a week. You mentioned that his PSA was low, what is his PSA history (PSA at diagnosis, after starting primary ADT, etc.)
AST and ALT elevated
Cause of steady increase in Alt (liver) score
High Blood Pressure and Secondary Therapy
High testosterone treatment
