BRAC2

[GFM887]

Received my gene panel a couple days ago won't see MO until Dec.

Researching now. Any insight would be appreciated. I'm castrate resistant.

Cancer stable at 3.5. I have two sons I have to inform.

8/31/2018- PGDX gene panel reported the following:

--Microsatellite stable

--Sequence mutations: BRCA2 (E1646G, E1646Kfs*24), EP300 (G194A), IDH2 (D225N).

--No amplification or translocations

***BRCA2 (E1646Kfs*24)- this mutation may render the patient potentially

responsive to PARP inhibitor such as Olaparib.

I feel blessed to have found this forum. Thank you all for sharing your wisdom.

[Tall_Allen]

There are a lot of clinical trials for PARP inhibitors. There's an open question as to whether they are any more effective than carboplatin (which your MO can prescribe).

[AlanMeyer]

Wifeofvet posted a message about Rubraca, a new PARP inhibitor. See: healthunlocked.com/advanced...

There's a link posted by pjoshea there that explains them and also one that I wrote.

Here are some relevant Wikipedia articles:

Carboplatin: en.wikipedia.org/wiki/Carbo...

PARP inhibitors: en.wikipedia.org/wiki/PARP_...

The articles are technical but very informative.

Best of luck.

Alan

[Rsdutcher7]

My husband (BRCA2+) is being seen by a Epigenetic specialist that combines IV’s with a 4 week Lupron and with the 2 together it has possibilities of not becoming castrate resistant. (As well as less side effects) We just started so time will tell. Dr Nezami.

[GFM887 in reply to Rsdutcher7]

Thank you all for the post. When I see my MO in December I'll post his thoughts and comments.

[Balsam01 in reply to Rsdutcher7]

IV of carboplatin combined with Lupron? May I ask where the idea that it resists castration resistance comes from?

[Rsdutcher7 in reply to Balsam01]

It’s not carboplatin or PARP Inhibitors although he does hold the patent on combining his treatments with PARP on woman with BRCA genes. It is a proprietary “out of pocket” blend. Very cutting edge and he’s had a LOT of success with Stage 4 cancer patients. Truly my husband is his 1st with the BRCA2 mutation though because it is rare in men.

[HopingForTheBest1 in reply to Rsdutcher7]

I recently had the Color genetic test, and am also BRCA2 pathogenic positive. I have two daughters who will need to get tested. As I am not currently castrate resistant, my MO does not recommend taking a PARP inhibitor at this point. I was diagnosed in June with Stage 4 PC to pelvic bone. I am on Eligard, Zytiga, Prednisone, and Xgeva. PSA now down from 20 to 0.2 after 3+ months of ADT treatment. Am participating in the SIMCAP clinical trial, and having robotic surgery Nov 14.

I was recommended to two of the top research centers that are doing alot of cutting edge research on this subject for both men and women. One is at UCSF, Dr Pamela Munster. The other is UPenn Basser Center for BRCA, Dr Susan Domchek. As I live in NJ, I have an appointment to meet with Dr Domchek in Philadelphia late December.

[Rsdutcher7 in reply to HopingForTheBest1]

You should be on track for quite some time with that plan. We just recently reached out to UCSF and started sending our paperwork. I’ll look up Dr Pamela Munster as we are only a few hours from San Francisco. Sounds like you’re hitting it hard with a multi-prong approach!

[HopingForTheBest1]

I am doing as much as I can that is within my control. I love to do research, which is essential to fight this disease. I have to be on top of my medical team as much as possible to ensure they are up to date on all current and soon to come out therapies, and that I understand all my viable options.

[Advo__cate in reply to HopingForTheBest1]

This is news to me. We have two daughters and thought we were in the clear as not having sons. Gene testing has not been mentioned or offered to us. So we ask the M.O. for this testing? Anything other heads up you can share with me?

[HopingForTheBest1 in reply to Advo__cate]

I was interested in genetic testing for awhile, since I have a significant family history of cancer. But no prostate history.

As part of my many second opinion meetings over the last few months, only one MO at Presbyterian recommended I have a genetic test. I had the saliva test from Color.com. Took about 10 days to get results. Cost just $99. To my total surprise I have BRCA2 mutation. Now it all makes sense to me as men who have BRCA2 are susceptible to advanced an aggressive PC, which I do have.

If you have the BRCA2 mutation, your daughters need to also be tested. Included in the test, the Color program provides a free consultation with a genetic counselor, which was very informative. I am also following up by having an upcoming appt with an expert geneticist at UPenn, Dr Susan Domchek.

[Advo__cate in reply to HopingForTheBest1]

Thank you.