How do I interpret PSA upload?

[joancarles]

Treated with Zytiga for 13 months. During my first 11 months the PSA has followed a decline in each reading. from 1350 to 0.17. But in the 12 month reading the PSA went to 0.19 and in the last reading of the month 13 to 0.26.

My doctor says I do not have to worry. But I want to know when it is interpreted that Zytiga is failing to work.

On the other hand, my Alkaline Phosphatase continues to fall in each reading.

Thanks friends

[Lombardi24]

It's a slow rise. It's not doubling. So is good for now.

[joancarles in reply to Lombardi24]

Thank you very much for the reply. we will continue fighting.

I hope everything goes well

[Dalph87]

PSA can bounce up and down slightly on Zytiga, it happened to my father as well.

Follow your oncologist advice and try to not worry!

Best wishes.

[joancarles in reply to Dalph87]

Thank you very much for the reply. I've heard about the rebound effect. I do not know what the acceptable oscillation is.

I will wait for future results to see a rebound effect or trend.

Very thankful.

I hope everything goes well

[Hidden in reply to joancarles]

I think it's a good sign that your ALK PHOS is still going down. And also the rise seems to be slow. Looks to me like you have some time. I would keep going with Zytiga for now.

What is your current Alkaline Phosphatase level?

[Dan59]

That is a fantastic response, there will be ups and downs in your psa, certainly more than the .1 you are having now, It is important to ride these ups and downs and get the most out of all these therapies. Some have a second response to zytiga by using dexamethasone as a steroid instead of prednisone, but you would certainly wait for significant consistant rises before doing this. I wish you the best

Dan

[Tall_Allen]

According to the latest criteria for PSA progression in research studies, PSA must reach a minimum of 1.0 ng/ml. But PSA alone is not enough -- there must also be signs of RADIOGRAPHIC progression before the therapy is declared failing. You are far from that.

[joancarles in reply to Tall_Allen]

You are always a great help to me. I hope in some occasion to be able to give a hand.

[dbrooks_h in reply to Tall_Allen]

What does RADIOGRAPHIC progression mean, In 3 years my psa has gone from 0.8 to 1.3 and back to 0.8.

[joancarles in reply to dbrooks_h]

Hello! Did this happen to you without changing the treatment at all? Have you been during these 3 years in Zytiga?

[dbrooks_h in reply to joancarles]

Only on Eligard, psa will not go any lower.

[joancarles in reply to dbrooks_h]

thanks for your answers. I hope you are well

[Tall_Allen in reply to dbrooks_h]

It means that the bone scan/CT or other imaging shows spread of the cancer

[dbrooks_h in reply to Tall_Allen]

Thanks Tall_Allen, I should have picked up on the word "radio" and related that to types of scans, have a very nice day......

[joancarles]

You are always a great help to me. I hope in some occasion to be able to give a hand.

[Hidden]

Joancarles, from 1350 I’d say that’s some drop . We all walk this dammed PSA phychological tight rope. Eat well stay moving And recovery shall come.. Stay 💪

[joancarles in reply to Hidden]

Thank you very much Lulu. You're right. It is difficult to live with this diagnosis and with the monthly analysis. But we will continue in the fight. I hope you are well.

[Hidden in reply to joancarles]

Thanks...I can’t complain..nobody

Wants to hear that sh##. chugging along... finding appreciation evertime I arise and feel love next to me.. I’m lucky to be alive...like that old dog named lucky.One eye, three legs, still lucky ...