Riluzole To Treat Advanced PCa - Look... - Advanced Prostate...
Riluzole To Treat Advanced PCa - Looks Promising
![gusgold profile image](https://images.hu-production.be/avatars/3f4bb9be0d77359f644e07c022a99698_small@2x_100x100.jpg)
![gusgold profile image](https://images.hu-production.be/avatars/3f4bb9be0d77359f644e07c022a99698_small@2x_100x100.jpg)
Thank you very much, paulofaus for the link.
There seems to be increased interest in accelerating androgen receptor [AR] degrading. Of course, PCa might respond by increasing AR expression (i.e. number) or by gain of function (AR amplification).
Natural substances found to increase AR degradation:
[1] Luteolin. (not lutein)
[2] Isosilybin B (from milk thistle)
[3] Curcumin
Semi-natural:
[4a] - [4j] ASC-J9 - Dimethylcurcumin, a synthetic curcuminoid
(The people in Rochester evidently see this as a money maker.)
Other:
[5a] Artemisinin
[5b] Carnosic acid
-Patrick
[1] ncbi.nlm.nih.gov/pubmed/180...
[2] ncbi.nlm.nih.gov/pubmed/183...
[3] ncbi.nlm.nih.gov/pubmed/219...
[4a] ncbi.nlm.nih.gov/pubmed/196...
[4b] ncbi.nlm.nih.gov/pubmed/223...
[4c] ncbi.nlm.nih.gov/pubmed/239...
[4d] ncbi.nlm.nih.gov/pubmed/240...
[4e] ncbi.nlm.nih.gov/pubmed/268...
[4f] ncbi.nlm.nih.gov/pubmed/270...
[4g] ncbi.nlm.nih.gov/pubmed/272...
[4h] ncbi.nlm.nih.gov/pubmed/292...
[4i] ncbi.nlm.nih.gov/pubmed/294...
[4j] ncbi.nlm.nih.gov/pubmed/302...