My PSA went from 1300 to 93. In the first 15 days. from 93 to 3 in the following 15. And in the following months has been falling progressively until reaching 0.18.
This way of descending tells us something?
My PSA went from 1300 to 93. In the first 15 days. from 93 to 3 in the following 15. And in the following months has been falling progressively until reaching 0.18.
This way of descending tells us something?
We are in the same doubt. Or maybe there is not a single answer.
My initial treatment has been Zytiga.
Thank you very much
Nalakrats
Yes, it tells you that his type of PC is very responsive right now to whatever treatment he had. In general, a lower nadir PSA is prognostic for a longer continued response.
Thank you very much Tall_Allen! Information of which I did not have knowledge.
It’s a good thing.. hope you go undetectable..and stay that way...
We instinctively wish for a robust PSA response. Unfortunately, that doesn't always correlate to a durable response.
It's nice to see one's PSA plummet, but I'd need the treatment protocol & a relevant survival study to be able to suggest what it might mean.
-Patrick
As previously state, the most important indicator for durable remission is if it goes to undetectible.(<.1)
I see that your treatment was Zytiga. PSA kinetics are definitely prognostic for overall survival after Zytiga treatment. Shorter time to PSA nadir, lower PSA nadir, and % PSA response by week 12 were all significant indicators of success
Thank you very much for the article.
I am in a clinical trial taking the untried mix of these meds:
Degarelix, Zytega, Apalutamide, Indomethicin, and Predizone.
After the 1st four weeks - PSA dropped from 9.1 to 0.91.
After the 2nd four weeks - PSA further dropped to 0.13.
I am less than 2 weeks away from the 3rd measured PSA (prior to undergoing RP).
I am diagnosed non-metastatic localized Gleason 9, with observed PNI.
So considering my diagnosis and lowered PSA, is nerve-sparing possible?
Does the clinical trial require you to have surgery?
Yes. Surgery is a 'component' of the trial. It is scheduled early June. The trial will take specimens from surgery for research. I signed on to the trial, yet as with all trials you have the option to leave at any time. So no, it is not 'required'. However I was offered the trial after I had chosen RP, prior to hearing about this trial. Hope this makes sense.
We will learn a lot about the effects of those early treatments on high risk cancer tissue. I think you are heroic to be part of that. Ordinarily, the surgeon can take progressive frozen sections with a pathologist standing by in order to preserve as much tissue as possible. But with the cancer cells all shrunken and architecturally altered by the treatment, I don't know if it's a useful thing to do or not. What does your surgeon say?
Tall_Allen, thanks for the kind words. I am not much a heroic, just someone making the best decision from facts I have and what I've learned. My Feb. biopsy revealed plenty of localized PC, with observed PNI in the right-side. I am fortunate my scans were found clear, yielding a diagnosis of non-metastatic and entry into this trial.
The PNI is the scary part for me now. It suggests my right-side nerve should be removed. My tallest prayer is my surgeon (along with my oncologist) can spare this nerve, based on lowered PSA and what is seen in surgery, as a result from taking this mix of ADT meds.