F.YI

[Steveo3312]

newsmax.com/t/health/articl...

[pjoshea13]

This story was posted 3 months ago, but I noticed that it is showing up as new again.

The odd thing about this is that although Pandolfi found that:

"The metastatic tumors produced huge amounts of lipids, or fats. In tumors that lacked both the PTEN and PML tumor suppressing genes, the cells' fat-production mechanism appeared to run wild."

... the story has this:

"A diet high in fat — such as that typically found in the United States — has long been suspected of fueling prostate cancer growth

"Dr. Pier Paolo Pandolfi, director of the Cancer Center and Cancer Research Institute at BIDMC knew that historically, data showed dietary fat linked many types of cancer, including prostate cancer.

"patients may be helped with the fat-blocking drug or through diet.

""The data are tremendously actionable, and they surely will convince you to change your lifestyle," Pandolfi said."

The body manufactures many types of fatty acids. PCa cells have altered fatty acid metabolism.

This is from a new sulforaphane [SFN] paper [1]:

"Increased de novo synthesis of fatty acids is a rather unique and targetable mechanism of human prostate cancer."

Now how is diet going to affect that? If we cut out fat altogether, is PCa going to stop making it?

The problem is upregulated fatty acid synthase (FASN) in the cancer cells.

"Treatment of androgen-responsive (LNCaP) and castration-resistant (22Rv1) human prostate cancer cells with SFN (5 and 10 μM) resulted in downregulation of ... fatty acid synthase (FASN) ... Immunohistochemistry revealed a significant decrease in expression of FASN ... in prostate adenocarcinoma sections of SFN-treated TRAMP mice when compared with controls."

-Patrick

[1] ncbi.nlm.nih.gov/pubmed/296...