I'm 74 and have stage 4 low volume PC. One lesion in the bone. My gleason 8 and psa now 1.2 from 34. I'm on Zytiga, prednesone, lupron and my enzymes were normal beore meds. I've been on Zytiga since Jan 18 and liver enzymes are now at AST 46 and ALT 78. I've been off Zytiga for 1 1/2 weeks and it has come down slightly. Will be retested in another 5 days. My oncologist wants to try 3 pills next and then maybe go to 2. I don't like the idea with toying with the liver and would rather go to 2 pills next if enzymes are normal. He is dead against supplements and is by the book. Any thoughts?