My dad (72) has Gleason 9 stage 4 Prostate cancer. He has been through all the standard hormone therapy, doxetaxel and is now on enzalutamide but is showing some resistance to it. The last three PSA tests have shown a rise. What options do we have next? We are in the UK. I am feeling very upset about this drug no longer working effectively and am hoping that there are some success stories with either resensitising to enzalutamide or more drugs. The oncologist said that Bipolar Androgen Therapy would not work given that hormone therapy has already failed... and that aptalutamide wouldn't work for long given that it uses the same mechanisms as enzalutamide. He did however say that there are new agents. There are some very clever people on this forum so I am hoping you can help me with this.