Lets say you have a rising PSA on Xtandi..with crossover resistance Zytiga will usually work for a few months. Hello Apalutamide..the problem here is Apalutamide is very similar to Xtandi and both drugs have a chemical structure based on Casodex...so if Apalutamide works you get maybe 3 months. Darolutamide is different...not based on Casodex and works on mutated ARs so there is a good chance this could work for 1-2 years...problem is Darolutamide is in a Phase 2 Clinical Trial...after Darolutamide fails you then move on to Proxilutamide which is 2-5 times stronger than Xtandi and is now in Phase 1 Clinical Trials...Proxilutamide should buy at least 1-2 years...after that there will be more drugs in early clinical trials...maybe even a vaccine that cures PCa.
Dr. Nalakrats stated he has developed a critical CO2 extraction of herbs that cures PCa....but after looking at the pic below of Dr. Nalakrats announcing his discovery, I think I will wait for the Right To Try legislation to be signed by the President.
Federal Right To Try Law will open the flood gates with immunity from lawsuits and no effect on eventual FDA approval.....with State RTT, Wrando's post below will be the rule not the exception...the average PCa patient will run against a brick wall from the drug companies
you are never far from needing new drugs...the key to surviving PCa is avoiding castrate resistance...when I tried to obtain Xtandi Humana turned me down because I was not castrate resistant....these idiots want you to become castrate resistant on Lupron and block access to every new drug out there until you are
Unfortunately the trials are set up with strict guidelines. These are EXPERIMENTS and you can't get good results from an experiment unless all your samples are within the parameters set up for the experiment. So if your case doesn't match the experiment parameters you won't be able to participate because your results would muddy the waters. They are not out to get you and there are no EEEVIL entities working hard on excluding you.
I've worked on financing for drug companies and the FDA process costs one hell of a lot of money and takes several years. During this time the drug companies are bleeding red ink with no guarantee they'll ever recoup their expenditures let alone get in the black.
Look, I'm Gleason 9, stage 4, castrate resistant. My oncologist says the chemo is the only thing keeping me alive and it's going to run out of effectiveness real soon. I'd love to get in a clinical trial that would show promise of getting me a few extra months. But I'm a realist. Nobody started any trials for Stegosaurus's personal benefit; it is unrealistic to ask anyone to derail the work they've been doing on the off chance it might help me. Much though I'd like that - ain't going to happen. Deal with it.
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Looking to be aggressive, but in the right way?
Hmm... Why am I on Zytiga?
Hormone therapy with the lutamides and keepin your testosterone intact
Between a rock and another rock...
