I previously wrote that ADT failed after 6 months and that I was looking at next steps. In summary
- RP in 2015, IMRT in 2016 both failed to stop disease progression
- PSA was 7.5 in Apr 2017 when I started ADT, by Nov 2017, PSA had reached 15.9.
Gregg57 suggested that the issue might be neuroendicrine PCa and and advised me to look out for visceral met.s.
So what has happened since then? Uro added Cosodex to my Zolodex and has conducted a series of tests:
- bone scan shows no bony metastisis
- CT scan showed 'suspicious lesions' in liver
- PSMA scan showed that lesions in liver are indeed PCa mets. Not the best Christmas present ever!
- PSA as at 19 Dec is 41.
In summary - ADT2 has done nothing to stop disease progression. MO has stopped Cosodex and ruled out Enza or Abiraterone as there is no 'androgen axis'. He also noted that this is not behaving like 'normal PCa'. So I need to start chemo right away (first dose scheduled 29 Dec). It has been encouraging to read the reports of many men here who have gone through chemo, and I am quite confident about managing side effects. Luckily at age 55 I am still fit and active, I don't run marathons like Randy Kam who is a member here but i am pretty fit for my age.
Gregg57 - you know your stuff, and unfortunately it looks like you called it correctly.
Thanks to everyone on this forum, the conversations and comradeship here make it easier to manage this disease. A Merry Christmas to each and every one of you!