Acne vulgaris & PCa: New Swedish study... - Advanced Prostate...

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Acne vulgaris & PCa

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New Swedish study.

"We identified a large cohort of young men born in Sweden between 1952 and 1956, who underwent mandatory assessment for military conscription around the age of 18 (n= 243,187)."

"The cohort was followed through linkages to the Swedish Cancer Register to identify the occurrence of prostate cancer until December 31st 2009."

"A total of 1,633 men were diagnosed with prostate cancer during a median follow-up of 36.7 years."

"A diagnosis of acne classified as severe conferred a 6-fold increased risk of prostate cancer."

The key is "severe".

A Dutch study found no connection with "self-reported" acne.

A U.S. study used 4 or more years of tetracycline use as evidence of severe acne.

-Patrick

ncbi.nlm.nih.gov/pubmed/292...

Int J Cancer. 2017 Dec 4. doi: 10.1002/ijc.31192. [Epub ahead of print]

Acne in late adolescence and risk of prostate cancer.

Ugge H1, Udumyan R2, Carlsson J1, Andrén O1, Montgomery S2,3,4, Davidsson S1, Fall K2,5.

Author information

Abstract

Accumulating evidence suggest that Propionibacterium acnes may play a role in prostate carcinogenesis, but data are so far limited and inconclusive. The aim of this population-based cohort study was therefore to test whether presence of acne vulgaris during late adolescence is associated with an increased risk of prostate cancer later in life. We identified a large cohort of young men born in Sweden between 1952 and 1956, who underwent mandatory assessment for military conscription around the age of 18 (n= 243,187). Test information along with health data including medical diagnoses at time of conscription was available through the Swedish Military Conscription Register and the National Patient Register. The cohort was followed through linkages to the Swedish Cancer Register to identify the occurrence of prostate cancer until December 31st 2009. We used Cox regression to calculate adjusted hazard ratios (HR) and 95% confidence intervals (95% CI) for the association between acne in adolescence and prostate cancer risk. A total of 1,633 men were diagnosed with prostate cancer during a median follow-up of 36.7 years. A diagnosis of acne was associated with a statistically significant increased risk for prostate cancer (adjusted HR: 1.43 95%; CI: 1.06-1.92), particularly for advanced stage disease (HR: 2.37 95%; CI 1.19-4.73). A diagnosis of acne classified as severe conferred a 6-fold increased risk of prostate cancer (HR: 5.70 95% CI 1.42-22.85). Data from this large prospective population-based cohort add new evidence supporting a role of P acnes infection in prostate cancer. This article is protected by copyright. All rights reserved.

KEYWORDS:

Propionibacterium acnes; acne vulgaris; inflammation; prostate cancer

PMID: 29205339 DOI: 10.1002/ijc.31192

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