Log in
Advanced Prostate Cancer
7,747 members8,021 posts

Interesting statement regarding PCa

"Studies have shown that the prostate cancer we see clinically in men in their 50-60s likely started while they were in their twenties or thirties."

33 Replies
oldestnewest

I believe that...I had "symptoms" for many years...a bit pronounced in late 30's...more so in my 40's...I kept telling myself, well, I'm older now, I'm out of shape - stupid rationales, I admit - then, @ 49 - bam! Pretty serious.

3 likes
Reply

That’s what I said to myself for years Just normal mid life crisis stuff. In denial and didn’t like going to doctors. I did the same thing until 53 .I had symptoms for five years. My Docs said this had been in me for years... looking back , it’s all 20/20. I was a pretty highly testosterone driven guy. The price of being macho. I didn’t pay attention to my health. I’m

Paying attention now. Live well and enjoy this life.

7 likes
Reply

I understand the Bam! Factor, now we’re paying attention..

1 like
Reply

Do you have links to studies?

How could a study possibly collect information that would enable it to form such a conclusion?

I am wondering what kind of evidence they could collect to support such a proposition.

Reply

The evidence is from autopsies.

"Autopsy studies have shown that approximately one third of men aged 40 to 60 years have histologically evident prostate cancer36; the proportion increases to as high as three fourths in men older than 85 years.37 Most cases represent microscopic, well-differentiated lesions that are unlikely to be of clinical importance. Increased frequency of PSA testing, a lower threshold for biopsy, and an increase in the number of core biopsies obtained all increase the detection of lesions that are unlikely to be of clinical significance."

uspreventiveservicestaskfor...

Hostologically evident means that they can see the cancer if they dissect the prostate, mount the tissues on slides, and apply the appropriate stains.

Since there was no link, it's hard to know how they concluded that the cancers started in the 20s and 30s. At that stage the cancer tumor is probably too small to be detected with a microscope. One way would be to project the very slow growth of the cancer back in time, but that's just a guess.

2 likes
Reply

"Most cases represent microscopic, well-differentiated lesions that are unlikely to be of clinical importance. Increased frequency of PSA testing, a lower threshold for biopsy, and an increase in the number of core biopsies obtained all increase the detection of lesions that are unlikely to be of clinical significance."

That is not the same type of cancer that we face.

Reply

I am trying to find where I read this...will apprise ASAP.

Reply

My urologist mentioned (Jan 2018) a study of autopsies in Detroit during a period where a large number of young men died prematurely. He gave a few figures from his memory of %'s of men autopsied in their twenties evidence of prostate cancer. I don't have the citation though.

Reply

That's scary as hell.

1 like
Reply

Another way to look at it is that the prostate naturally changes as we age. The question is why most of those lesions never grow, but some do.

Growing old, even with increasing risk of cancer, is great when you consider the alternative.

1 like
Reply

Poor cadavers!

Reply

You may be interested in this chart from an autopsy study:

urology.ucla.edu/body.cfm?i...

4 likes
Reply

Amazing findings, just mind boggling.

Thanks, Tall_Allen.

Reply

I do believe it.

Reply

That's what I get for being a horny kid...

Good Luck and Good Health.

j-o-h-n Saturday 05/05/2018 1:38 AM EDT

Viva Mexico!

3 likes
Reply

Did that change as an adult?

Reply

Yeppers Peppers... I got hornier...

Good Luck and Good Health.

j-o-h-n Saturday 05/05/2018 7:12 PM EDT

1 like
Reply

The plight of the testosterone laden males ...

Reply

So true, some of our issues are tied to no testosterone. Just last night at the mall, I couldn’t find a thing in the women’s shoe......

3 likes
Reply

Me too. I can’t find no size 13 pumps ....

Reply

and to the joy of females...

Good Luck and Good Health.

j-o-h-n Sunday 05/06/2018 5:15 PM EDT

1 like
Reply

Oh yah! Gods gift to women. A horny guy.. not talking about you. Just myself. God bless you. Thanks as always.

Reply

As I recall Lulu, you said goodbye to the boys as I have.... I've often thought... since there ain't nothin to scratch anymore and it is "as soft as a pony's nose" (to quote), what about a pair of silk granny panties instead of the ole tightie whities? That'd be the day I'd have a heart attack and get rushed in an ambulance.

2 likes
Reply

Yah , yah, now you’re talking. Women know how to be comfortable and compassionate. Men can learn a lot by thepositive female traits of which there are many.. I hate wearing undies or even pan5s. I’d be a full time nudist.. I can’t take any pressure of even an elastic waste band or even the car seatbelt against my RT site. How bout a kilt or a loin cloth? No friction there.. if we can’t laugh at us macho guys . Who can we laugh at .. I’m a pussy now , a ridiculously low threshold of pain.. I’m feminized... I am a feminist now. On the ladies side.. I’ve always loved women more than men . Now I am one.. CANT BEAT . JOIN EM . ONLY TOOK ME 57 yrs to figure that one out.. Beside Healthunlocked no guys want to talk or hear about this kind of shit. Because they don’t want it to rub off on them.. At least WE know our Achilles heal and we are dealing with it. I stop all of my bad habits 3yrs ago . My docs say my blood is better than theirs. Don’t know if that’s saying much. For me the surgery as kind of trike that guy in Moab Utah that cut his arm off to free it froma boulder and his sure death. That’s a bad ass young man. We do what we feel is right for us to stroll around a little longer and appreciate the views along this twisted APC path. Let’s go fishin!

Reply

Let’s Stay out of that ambulance Cumpadre!

Reply

I was treated for a prostate infection many times in my late 30’s and 40’s. Looking back, those were the first inflammatory periods I can remember.

2 likes
Reply

Me too: prostatitis at 40 , bph from 55-69, PCa dx at 69!

1 like
Reply

I had symptoms several years before dx. Just didn't know it at the time. Men need to become aware of their bodies and what it is telling us. Look at how much more women are into being aware of changes in the bodies.

3 likes
Reply

Yep started seeing the urologist for a hard spot on the prostate at 36. Was seeing my doctor every 6 months for the last 20 years. Then at 66 the bomb was dropped. Stage 4

1 like
Reply

The bomba was droppeth...The hammer fell the other shoe dropped.. At least we know our lot and our nemesis.

Reply

Perhaps in the future the testing protocol will change. When my PSA hit 4.0 I had a biopsy, Gleason score of 9, then a radical prostatectomy where I was already at stage IV. In the future there may be a way to catch the PC before it leaves the prostate.

3 likes
Reply

That would have been optimum. I too didn’t see’ help until nearly caput...

1 like
Reply

Same for me. By the time my PSA reached 4.3, I was too far gone! My surgeon said that I probably had PCa for many years. My older brother had an RP when his PSA was 2.2, Gleason 6...his is fine 17 years post-op. I wish I had caught mine at least 5 years earlier when my PSA was around 2.0.

1 like
Reply

You may also like...