Interesting statement regarding PCa

[E2-Guy]

"Studies have shown that the prostate cancer we see clinically in men in their 50-60s likely started while they were in their twenties or thirties."

[spinosa]

I believe that...I had "symptoms" for many years...a bit pronounced in late 30's...more so in my 40's...I kept telling myself, well, I'm older now, I'm out of shape - stupid rationales, I admit - then, @ 49 - bam! Pretty serious.

[Hidden in reply to spinosa]

That’s what I said to myself for years Just normal mid life crisis stuff. In denial and didn’t like going to doctors. I did the same thing until 53 .I had symptoms for five years. My Docs said this had been in me for years... looking back , it’s all 20/20. I was a pretty highly testosterone driven guy. The price of being macho. I didn’t pay attention to my health. I’m

Paying attention now. Live well and enjoy this life.

[Hidden in reply to spinosa]

I understand the Bam! Factor, now we’re paying attention..

[cesanon]

Do you have links to studies?

How could a study possibly collect information that would enable it to form such a conclusion?

I am wondering what kind of evidence they could collect to support such a proposition.

[FCoffey in reply to cesanon]

The evidence is from autopsies.

"Autopsy studies have shown that approximately one third of men aged 40 to 60 years have histologically evident prostate cancer36; the proportion increases to as high as three fourths in men older than 85 years.37 Most cases represent microscopic, well-differentiated lesions that are unlikely to be of clinical importance. Increased frequency of PSA testing, a lower threshold for biopsy, and an increase in the number of core biopsies obtained all increase the detection of lesions that are unlikely to be of clinical significance."

uspreventiveservicestaskfor...

Hostologically evident means that they can see the cancer if they dissect the prostate, mount the tissues on slides, and apply the appropriate stains.

Since there was no link, it's hard to know how they concluded that the cancers started in the 20s and 30s. At that stage the cancer tumor is probably too small to be detected with a microscope. One way would be to project the very slow growth of the cancer back in time, but that's just a guess.

[cesanon in reply to FCoffey]

"Most cases represent microscopic, well-differentiated lesions that are unlikely to be of clinical importance. Increased frequency of PSA testing, a lower threshold for biopsy, and an increase in the number of core biopsies obtained all increase the detection of lesions that are unlikely to be of clinical significance."

That is not the same type of cancer that we face.

[E2-Guy in reply to cesanon]

I am trying to find where I read this...will apprise ASAP.

[notjohn in reply to E2-Guy]

My urologist mentioned (Jan 2018) a study of autopsies in Detroit during a period where a large number of young men died prematurely. He gave a few figures from his memory of %'s of men autopsied in their twenties evidence of prostate cancer. I don't have the citation though.

[Hidden]

That's scary as hell.

[FCoffey in reply to Hidden]

Another way to look at it is that the prostate naturally changes as we age. The question is why most of those lesions never grow, but some do.

Growing old, even with increasing risk of cancer, is great when you consider the alternative.

[Hidden in reply to Hidden]

Poor cadavers!

[Tall_Allen]

You may be interested in this chart from an autopsy study:

urology.ucla.edu/body.cfm?i...

[whatsinaname in reply to Tall_Allen]

Amazing findings, just mind boggling.

Thanks, Tall_Allen.

[Hidden]

I do believe it.

[j-o-h-n]

That's what I get for being a horny kid...

Good Luck and Good Health.

j-o-h-n Saturday 05/05/2018 1:38 AM EDT

Viva Mexico!

[Hidden in reply to j-o-h-n]

Did that change as an adult?

[j-o-h-n in reply to Hidden]

Yeppers Peppers... I got hornier...

Good Luck and Good Health.

j-o-h-n Saturday 05/05/2018 7:12 PM EDT

[Hidden in reply to j-o-h-n]

The plight of the testosterone laden males ...

[TenscTexan in reply to Hidden]

So true, some of our issues are tied to no testosterone. Just last night at the mall, I couldn’t find a thing in the women’s shoe......

[Hidden in reply to TenscTexan]

Me too. I can’t find no size 13 pumps ....

[j-o-h-n in reply to Hidden]

and to the joy of females...

Good Luck and Good Health.

j-o-h-n Sunday 05/06/2018 5:15 PM EDT

[Hidden in reply to j-o-h-n]

Oh yah! Gods gift to women. A horny guy.. not talking about you. Just myself. God bless you. Thanks as always.

[TenscTexan in reply to Hidden]

As I recall Lulu, you said goodbye to the boys as I have.... I've often thought... since there ain't nothin to scratch anymore and it is "as soft as a pony's nose" (to quote), what about a pair of silk granny panties instead of the ole tightie whities? That'd be the day I'd have a heart attack and get rushed in an ambulance.

[Hidden in reply to TenscTexan]

Yah , yah, now you’re talking. Women know how to be comfortable and compassionate. Men can learn a lot by thepositive female traits of which there are many.. I hate wearing undies or even pan5s. I’d be a full time nudist.. I can’t take any pressure of even an elastic waste band or even the car seatbelt against my RT site. How bout a kilt or a loin cloth? No friction there.. if we can’t laugh at us macho guys . Who can we laugh at .. I’m a pussy now , a ridiculously low threshold of pain.. I’m feminized... I am a feminist now. On the ladies side.. I’ve always loved women more than men . Now I am one.. CANT BEAT . JOIN EM . ONLY TOOK ME 57 yrs to figure that one out.. Beside Healthunlocked no guys want to talk or hear about this kind of shit. Because they don’t want it to rub off on them.. At least WE know our Achilles heal and we are dealing with it. I stop all of my bad habits 3yrs ago . My docs say my blood is better than theirs. Don’t know if that’s saying much. For me the surgery as kind of trike that guy in Moab Utah that cut his arm off to free it froma boulder and his sure death. That’s a bad ass young man. We do what we feel is right for us to stroll around a little longer and appreciate the views along this twisted APC path. Let’s go fishin!

[Hidden in reply to Hidden]

Let’s Stay out of that ambulance Cumpadre!

[Don1157]

I was treated for a prostate infection many times in my late 30’s and 40’s. Looking back, those were the first inflammatory periods I can remember.

[Break60 in reply to Don1157]

Me too: prostatitis at 40 , bph from 55-69, PCa dx at 69!

[mcp1941]

I had symptoms several years before dx. Just didn't know it at the time. Men need to become aware of their bodies and what it is telling us. Look at how much more women are into being aware of changes in the bodies.

[larry_dammit]

Yep started seeing the urologist for a hard spot on the prostate at 36. Was seeing my doctor every 6 months for the last 20 years. Then at 66 the bomb was dropped. Stage 4

[Hidden]

The bomba was droppeth...The hammer fell the other shoe dropped.. At least we know our lot and our nemesis.

[tallguy2]

Perhaps in the future the testing protocol will change. When my PSA hit 4.0 I had a biopsy, Gleason score of 9, then a radical prostatectomy where I was already at stage IV. In the future there may be a way to catch the PC before it leaves the prostate.

[Hidden in reply to tallguy2]

That would have been optimum. I too didn’t see’ help until nearly caput...

[E2-Guy in reply to tallguy2]

Same for me. By the time my PSA reached 4.3, I was too far gone! My surgeon said that I probably had PCa for many years. My older brother had an RP when his PSA was 2.2, Gleason 6...his is fine 17 years post-op. I wish I had caught mine at least 5 years earlier when my PSA was around 2.0.