New study below.
PSMA is prostate-specific membrane antigen. A cautionary naming tale is that of prostaglandins. Discovered in prostate tissue in 1935 - & later, wherever researchers looked. Nevertheless, we later have prostate-specific antigen [PSA], which is not even gender-specific, & then, prostate-specific membrane antigen.
"Currently, the findings of imaging procedures used for detection or staging of prostate cancer depend on morphology of lymph nodes or bone metabolism and do not always meet diagnostic needs. Prostate-specific membrane antigen (PSMA), a transmembrane protein that has considerable overexpression on most prostate cancer cells, has gained increasing interest as a target molecule for imaging. To date, several small compounds for labelling PSMA have been developed and are currently being investigated as imaging probes for PET ..." [2]
Intro. to the new paper:
"Prostate-specific membrane antigen (PSMA), a type II transmembrane glycoprotein receptor, is highly expressed in prostate cancer and in the tumor neovasculature of colon, breast, and adrenocortical tumors."
"PSMA is significantly overexpressed in the neovasculature of {primary differentiated thyroid cancers [TCa]} compared with normal and benign thyroid nodules ..."
Thyroid cancer is of interest because a PCa diagnosis increases the probability of a TCa diagnosis - & vice versa.
Both cancer types have been described as being over-diagnosed, & men with both as being victims of over-screening.
I wonder how PSMA-PET imaging for PCa will affect TCa detection?
-Patrick
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