My PSA & Scan History

My PSA & Scan History

I thought that I would share my PCa & APCa history in the hopes that early chemotherapy may help you as it has helped me. You will readily see that my journey is unlike the greater percentage of men diagnosed. Many believe that there is no cure for this bastard disease. I and several others know otherwise. There is hope! Good luck and Keep Kicking the Bastard.

Gourd Dancer

9 Replies

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  • Great result, gives me inspiration - starting Docetaxel in a few weeks.

  • This is the trial in which I was enrolled.

    Cancer Chemother Pharmacol. 2013 Jun;71(6):1629-34. doi: 10.1007/s00280-013-2163-4. Epub 2013 Apr 21.

    A phase II trial of androgen deprivation therapy (ADT) plus chemotherapy as initial treatment for local failures or advanced prostate cancer.

    Amato R1, Stepankiw M, Gonzales P.

    Author information

    •1Division of Oncology, Department of Internal Medicine, University of Texas Health Science Center at Houston (Medical School)/Memorial Hermann Cancer Center, 6410 Fannin St., Suite 830, Houston, TX 77030, USA. robert.amato@uth.tmc.edu

    Abstract

    PURPOSE:

    Long-term hormonal ablation in prostate cancer is associated with decreased overall health and quality of life. Few reports emphasized the role of chemotherapy in the management of early stage prostate cancer. This study analyzed the safety and efficacy of androgen deprivation therapy (ADT) plus chemotherapy as initial treatment for patients identified as local failures or not eligible for prostatectomy or radiation therapy due to advanced disease presentation.

    METHODS:

    Enrolled patients received ADT in the form of leuprolide every 12 weeks for 24 months with bicalutamide initiating after the completion of chemotherapy. Chemotherapy consisted of ketoconazole and doxorubicin for weeks 1, 3, and 5 and estramustine and docetaxel and for weeks 2, 4 and 6. During weeks 7 and 8, no treatment was received.

    RESULTS:

    Forty-six patients were enrolled, and forty-five patients were evaluable. Median progression-free survival (PFS) was 23.4 months. Median overall survival (OS) was 53.7 months. Out of 45 patients with measurable disease, 22 patients had an objective response: 9 patients achieved a complete response; 2 patients achieved a partial response; 10 patients achieved stable disease. Frequent grade 3 adverse events included elevated ALT (17 %), hypokalemia (13 %), and hypophosphatemia (13 %). Grade 4 adverse events were rare and included low bicarbonate (2 %), hypokalemia (2 %), leukocytopenia (2 %), and neutropenia (2 %).

    GD

  • Thank you so much

  • Initial PSA of 6+, treated with seeds and radiation. Progressed to PSA 32 and mets. Chemo. Then iADT. Off ADT. Now, PSA=0, T=400. Looks good.

  • No, not intermittent ADT. injection every 3 months for seven years. Then stopped to test whether I still needed the Lupron. Dr. A suggested, and told me that if he was wrong, then, I could simply restart the injections. that was seven years ago.

    GD

  • Thanks for sharing the details of your treatment. What was the chemo treatment you received in 2004? Always good to hear good results.

  • METHODS:

    Enrolled patients received ADT in the form of leuprolide every 12 weeks for 24 months with bicalutamide initiating after the completion of chemotherapy. Chemotherapy consisted of ketoconazole and doxorubicin for weeks 1, 3, and 5 and estramustine and docetaxel and for weeks 2, 4 and 6. During weeks 7 and 8, no treatment was received.

    RESULTS:

    Forty-six patients were enrolled, and forty-five patients were evaluable. Median progression-free survival (PFS) was 23.4 months. Median overall survival (OS) was 53.7 months. Out of 45 patients with measurable disease, 22 patients had an objective response: 9 patients achieved a complete response; 2 patients achieved a partial response; 10 patients achieved stable disease. Frequent grade 3 adverse events included elevated ALT (17 %), hypokalemia (13 %), and hypophosphatemia (13 %). Grade 4 adverse events were rare and included low bicarbonate (2 %), hypokalemia (2 %), leukocytopenia (2 %), and neutropenia (2 %).

  • Even with my calibrated eyeball, I had a tough time with it. But, I was able to see that your Psa was low, while you had some real T going on. You've done well, kudos.

  • Thanks Joe, I did not know any other method to attach a file other than an image. Save and then expand with say Windows Live Photo Gallery or any of the common jpeg readers. I took an Excel file and saved to a pdf and then used Photoshop to combine two pages into one jpeg image.

    GD

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