I would like everyone to understand that Prostate Cancer disease progression is aided by inflammation. Inflammation reduces the effectiveness of all chemotherapeutic agents no matter how mild, such as plant based Phytoestrogens, or how harsh, such as Cabazitaxel which requires other IV based medications to manage it's adverse patient responses. The simple immune response caused by dying cancer cells that results from any type of chemotherapy causes many different types of immune response that may adversely affect patient treatment outcomes.
PCSPES Is a herbal substance known to extend survival time in some patients. PCSPES was recalled due to contamination at the order of the FDA around or about 2001. It is very important that anyone considering the use of this substance familiarize themselves with it's history as published by the National Institutes of Health: cancer.gov/about-cancer/tre... ... Subsequent research has identified a number of properties created by this mixture of traditional Chinese herbal formulation that have been used to manage PCa problems. Although PCSPES has been shown to extend survival times there are other, perhaps better, alternatives....
NISADS produce some mild anti inflammatory results while the results with Corticosteroids such as Predisone have been profound. 30 years of research with Cortecosteroids shows that they are perhaps the most effective therapy for reducing inflammation, for reducing allergic reactions to chemotherapeutic agents, for slowing disease progression at all stages, and for extending survival time when used with your primary chemotherapeutic agent.
Of all of the Cortecosteroids Predisone in as low a dose as 5 mg/TID/daily, is the most researched and perhaps the best drug available to extend your life at all stages of disease progression:
As regards the reduction of both bone mass and muscle weakening:
At any point, but particularly when beginning, ADT question your provider about Intermittent forms of therapy. Enabling your body to recover for brief periods until your PSA rises to a threshold you both agree on, usually somewhere between 10 and 20, which allows your body to regain its health. If your on Intermittent Lupron discuss whether a course of Intermittent Casodex might be beneficial. These drugs both reduce your PSA but the way in which they attack the problem differs. Casodex blocks Androgen but leaves a small amount of Testosterone, which will help in maintaining muscle mass when you excercise and reduce carbs. Switching at Intervals between these two drugs has some anecdotal support for extending life but there is no definitive research available to support the proposition.
Lyposomal vitamin C, Calcium, vitamin D, Magnesium L-Threonate, Potassium and Pao Pereira as well as a minimal dose of NSAIDs, and the Cortecosteroid Predisone may help manage inflammation, symptoms, and slow disease progression "especially" following biochemical failure after a treatment with intent to cure such as a prostatectomy or radiation.
By treating the inflammation you can extend survival time. Aspirin is suggested. For those who cannot take aspirin, Zyflamend is also an analgesic to treat inflammation.
Low dose aspirin is 81mg daily and commonly available. A significant body of research exists that has both been verified and supported by the biomedical research programs at well known Universities. Harvard offers a number of opinions supporting a significant reduction in mortality when taken over long periods of time.
Those taking Casodez for ADT should discuss starting an aspirin regimen ASAP with both their Oncologists and their Cardiologist as Casodez is known to have cardiac risks which may be reduced by an aspirin regimen.
"as Casodez is known to have cardiac risks which may be reduced by an aspirin regimen." could you provide a link or reference to the above: For, I would like to read that article and learn more about it.
I suggest reviewing this NIH report for a review of the historical basis of my concern related to heart diseases and prostate cancer bearing in mind that both this and liver disease are two of the severe risk factors for Casodex with long term ADT :
My access to the American Journal of Clinical Oncology has been limited due to my retirement so I am unable to do search at will without an institutional subscription however if you are able to gain access to the Journal you will find a number of articles discussing current research on aspirin's role in reducing morbidity and mortality. Please bear in mind that the literature frequently supports low dose aspirin at 81 mg. and very rarely supports moderate or high dose aspirin therapy. Aspirin is not reported as contraindicated with Casodex when researched in drug reactions by drug reaction information providers such as WEB MD, however a reasonable person taking Casodex should question the role of both Aspirin and Casodex in liver disease with their physician provider.
Thank you for your effort, it was a good read. I have my liver checked every six months {blood test}. I take aspirin. I am a diabetic; however, without drugs my A1C is 5.8 Mu blood pressur is 120/78 with drugs including a beta blocker. I am on 150 mg, daily Casodex, my Psa is 6.7 from 105 a year ago. My two pelvic lymph nodes have been reduced by 40%, 1.9 centimeters. My cholestrol feom 253 is 109. I lost 100 lbs in two years by proper diet.
I would appreciate your anecdotal description of your personal response to Casodex so that our readers gain insight as to all aspects of this drug as an alternative to ADT treatment with Lupron which is often the first choice of most oncologists following biochemical failure.
IE:
Anecdotally, I take a three month supply of Lupron, administered by injection. Once my PSA has declined to less than two I either take another shot (during the winter when the sun is no longer as available to keep my body producing enough vitamin D I hestitate to experiment. I take a prescribed vitamin D supplement and continue my ADT without interruption or I skip it allowing myself time to recover.) When my PSA passes 10 I restart administration.
In my case Lupron causes itching, first at the sight of administration, then at the groin and armpits, then all over progressively. If I take 5 mg. of Predisone twice daily this reduces or eliminates all of the itching. My PSA does not begin to climb for at least several months.
If I take Lyposomal vitamin C, magnesium threonate, and Pao Pereira along with the Prednisone my PSA does not rise for over 5 months and I can stop the admistration of Lupron, feel better, and wait until it once again my PSA passes my threshold of 10 ....
.... Casodex is now being, has been used, in some cases as stand alone ADT therapy. Since Casodex reduces Androgen but leaves residual Testosterone it is hypothesized that this may result in less fatigue and loss of muscle mass. Switching from either Casodex to Lupron or Lupron to Casodex at the first sign of Androgen refractory / hormone resistant disease has been hypothesized as a potential ADT treatment time extender. At this point I believe PCa patients require more anecdotal reports from patients following ADT protocols for either drug so that they can speak with their Oncolgists about a strategy to prolong responsiveness.
Thank you for your posts here, Attitude67. What is in your Rx Vitamin D supplement?
I'm taking 10,000 IU of D3 plus good sun exposure plus a good baseline serum D level to maintain a high D level, which is associated with longer PCa survival. I recommend that people ask their doctor to test to get a baseline level, & then test periodically to see whether they're supplementing sufficiently.
For a non-Rx Vitamin D supplement, IT'S ESSENTIAL TO GET D3. Very inexpensive.
I would also like to point out that aspirin is acetylsalicylic acid (ASA). It is formed in many different shapes with a binder and may include additives such as powdered sugar, food dies, clay, and numerous other substances that are not only not beneficial to PCa patients avoiding carbs but may pose a risk as triggers for allergies and other types of inflammation.
The cheapest generic form of the substance is the best with nothing else added... If your not sure about what your buying consult your local pharmacist who will usually be only to happy to help.
If it's low dose and you have no problems taking it then taking one on an empty stomach and following that with some flax toast or oatmeal works for me.
I started taking theracumin to relive inflammation induced rotator cuff injuries that only pain killers had been able to relive in the last 6 years.
I have now been taking theracumin for about 2.5 yrs.
6 mths after starting theracumin which totally removed all shoulder pain (was very intense before) I was diagnosed with prostate cancer Gleason 7.
during treatment I had to stop the theracumin as it is a strong antioxidant and radiation treatment is supposed to work via oxidation.
I can highly recommend theracumin as a very natural and affective inflammation treatment.
Do not combine Theracumin with NSAIDs or other blood thinning supplements or pain killers as they all thin the blood. I had flu recently and took Ibuprofen to help with pain, result was dramatically increased bleeding, had to switch to Tylenol. (bleeding is from ongoing radiation induced proctitis, normally under control..)
Pomi-T (medscape.com/viewarticle/80... which also has cumin in it (theracumin is more bio available) showed excellent results from a UK test. I also have been taking Pomi-T, might be another reason for my blood thinning experiences with Ibuprofen..
I also found resistance exercise very good to reduce fatigue from hormones.
I like your report on POM-T use. I believe it is one of the better formulations for a mild phytoestrogen + naturopathic nutritional supplement. As I've said before I personally believe everyone who can afford it should search for a Naturopathic physician who is a member of the American College of Alternative Medicine. They do have insights and knowledge that may help you fight this disease. The fact that they are ACAM certified protects you from quackery and offers a wide spectrum of cross boarded family practioners and internists. It does not replace having a good Oncologist specialized in PCa or a Urologist who can treat any number of problems caused by either the disease or treatment.
POM-T research was presented at ASCO 2013. The European study was from Cranfield University based out of Bedford Hospital and it reported that the medical grade nutritional supplement formulation POM-T which is made of the extracts of pomegranate, green tea, turmeric and broccoli, was shown to provide a decrease in PSA doubling times.
(200+ men taking the whole food supplement (Pomi-T) had a significantly lower median percentage rise in PSA compared to men taking a placebo (P<0.0001). The difference in percentage rise in PSA between these groups from the start to end of the study was large (63.8%); and as the patient characteristics were well-balanced and the trial had sufficient numbers to ensure adequate statistical power, the results of this study offer clinically meaningful guidance for men contemplating nutritional supplements after prostate cancer)
Researchers have reported that future trials will look at continuing the intervention for longer periods of time and will include men with different stage of disease
Theracumin is another matter. Although authors report research indicating the substance bioactively reduces inflammation there is no commercialy viable test for blood levels so the evidence is primarily anecdotal. I am glad that it's working for you. I know many Naturopathic practioners use it however I think that Cortecosteroids offer a far greater potential for extending lives based on the body of research available at this time.
I do understand that you were looking for a mild biological that brought relief and I'm glad you found it useful. I'm sure that everyone who reads this will be able to add it to their pharmacopeia should they choose, however as reported in JU and cited many times since anyone on any form of ADT is at risk of Osteoporosis.
.J Urol. 2002 May;167(5):1952-6:
"There is evidence of decreased bone mineral density with all types of androgen deprivation therapy, presumably due to its anti-testosterone effect. Bone mineral density loss is 3% to 5% yearly in the first few years of androgen deprivation therapy with an increase in osteoporotic fracture incidence. There are little data on potential treatments, although bisphosphonates and intermittent androgen deprivation therapy may have salutary effects."
This is a the reason for taking Calcium and D as well as getting enough sun to make it work. Calcium and D are also recommended for anyone taking more than 7.5 mg of Predisone daily for the same reasons however less than 10 mg. Is still considered a low dose and is far less than you might be given for arthritis, asthma, or several other ailments. Your physician should be willing to help you weigh the risk because there is a large body of research reported over the years by NIH that indicates that 5 to 10 mg. of Predisone administered with almost any ADT drug is of great benefit in suppressing a rising PSA and extending the time before the patient must switch to another ADT drug or to treatment for castration resistant disease.
Personally I want to encourage everyone, myself included, to fight and live long enough to see and perhaps be saved by their own Killer T Cells targeting and killing their cancer. Anything that increases patient doubling times must be considered and when the risks justify it attempted...
I totaly agree about risk and reward, I am looking for a "strong biological anti inflammatory " not a mild one! I have had 1yr of hormone treatment and technically have ostopenia, which is why I am always on the look out for a way to reduce inflamation which does not increase my osteoporosis risk. Do you know of any reasearch that rates anti-inflamatory treatments/supplements by there relative effectiveness ?
I have read that inflammation is also made up of several specific types, any idea where prostate related inflamation fits into theses sub types of inflammation? Knowing this would help us chose rhe best anti inflammatory agent.
According to Associate Professor Gautam Sethi from the Department of Pharmacology at the Yong Loo Lin School of Medicine at the National University of Singapore (NUS) they have found that nimbolide, a bioactive terpenoid compound derived from Azadirachta indica or more commonly known as the neem plant, may reduce the size of prostate tumor by up to 70 per cent and suppress its spread or metastasis by half. Apparently their research showed that over 12 weeks a reduction of prostate tumor size by up to 70 per cent and a decrease in tumor metastasis by up to 50 per cent occurred ....
Seems the apostasis related results were quite significant , if not preliminary . This particular study however was a mouse study , correct ? Would be promising ! Thanks for sharing .
Here is the original investigative report for your review. It is a mouse study, however it was initiated as a result of anecdotal evidence suggesting the neem plant induced aptosis. It is not uncommon for Asian herbalists to formulate tinctures and other substances tailored to a disease. Neem was first noticed to have some effect at shrinking Pancreatic tumors. Pancreatic cancer has little survivabilty making any biological with potential a candidate for investigation. The fact that PCa cell lines respond well to it suggests that some formulation will be available shortly.
Neem from Singapore is a normal part of the herbal pharmacopeia there. Nimbolide is derived from the plant. Should you or anyone you know who is involved in biomedical research wish to investigate the substance this is the current information:
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