Treatment Can Increase Cancer Agressiveness

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newsmax.com/Health/Health-N...

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The idea is that the cells which the treatments bring to the tumor, for repair and cleanup, (macrophages, for one at least) sometimes facilitate the transition of the remaining cancerous epithelial cells to transition to mesenchymal cells, which are the kind that travel in the blood to settle in the bones, using the same natural mechanism that healthy osteoblasts use to settle there in the bone.

The article does not say how this will affect treatment ideas, or when, but I think that this is an area that transplant people have some expertise in - slowing down the immune system when you want to slow it down.

see wikipedia for Tumor Associated Macrophages

en.wikipedia.org/wiki/Tumor......

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This is in addition to the normal mechanism of evolution, ie of death, to change a population. Sine the treatments are causing death, they are opening the opportunity for evolution to manifest. The cancer cells are making copies, incorrect copies, and the thing they are copying is the mechanism to make copies. So if there is a population of cell types A B and C, and the A variant is killed by a treatment, now you have B and C that are sharing the environment without competition from A. And the pair acts differently from the trio. The change from A to B to C is in most cases by having parts break and fall off, but the cell has a lot of tricks buried in the DNA. Each cancer cell has the blueprint to make teeth one imagines., and let's hope they don't.

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Here is a video by Ken Pienta from Johns Hopkins on the topic

youtu.be/kU-hioJ81wA(Not working as expected?)