I'd like to ask a question of those who have taken or are taking ketoconazole. How long does it take to take effect? I am concerned because after two months of use, my PSA has not come down significantly. I started the high dose of 400 mg three times a day two months ago when my PSA was 17. After one month, it came down to 12 and I was encouraged, thinking that maybe it just takes a while to reach nadir. Then a few days ago at the end of the second month, I had my PSA checked and it is back to 15. Is there something I am doing wrong?