Has anyone experienced an early alkaline phosphatase bounce after starting Zytiga? Please see link below. Apparently, an early, significant increase of ALP in the first 2-4 weeks is a positive indicator of response to Zytiga, preceding a PSA decline.
Ex had a 30% reduction of PSA in the first 8 weeks of treatment, from 136 to 99. At 8 weeks he had an ALP bounce from 100 to 751. At 10 weeks, his ALP was within normal limits but PSA increased from 92 to 186. Unsure at this point if he is having a positive or negative response. He failed Xtandi in 4.5 months. Diagnosed 15 months ago.