Hi fellow sufferers. I was disagnosed with Wegeners GPA in June 2014 after suffering bad joint pain, swellings etc. for a couple of years and then 12 months or so before diagnosis it progressed with mega sinus problems, face and headaches and then hearing loss in both ears. Since then I have had grommets inserted in both ears on two occasions and the normal treatment of cyclophosphomide and prednisolone. Since August I have been taking methetrexate and am still on 10 mg of pred daily. However I have been having some blood loss from my nose since on the methx, at first just 1/2 weekly, but this week 1/2 daily and am wondering if anyone else has had this reaction? I am wondering if it is a reaction to the methx or just coincidental. I am due to see my rheumatologist again in 2 weeks and obviously will inform him.