The Beneficial Effect of L-Thyroxine on Cardiovascular Risk Factors, in Subclinical Hypothyroidism: Randomized, Crossover Trial

This 2007 UK study: a) got their participants from asking GP's if they 'minded' the patient being contacted and b) used 'subclinical hypothyroid' participants with any TSH over 4 for their study.

Does this mean that firstly, GP's actually do control who gets to take part in these trials? and secondly, how can they use people who have a TSH greater than 4 for such well run studies if WE are told that anything under 10 IS NOT hypothyroid?

On an older note in Italy in 2002 a similar study on heart diesase and Chloresterol levels etc subclinical hypos were in the 3.65 - 15 bracket but their 'controls' that is everyone else who was considered healthy were in the 0.63 - 2.65 bracket.

This has got to imply that anyone who goes over 2.65 WAS NOT CONSIDERED HEALTHY!

Lipoprotein Profile in Subclinical Hypothyroidism:

Response to Levothyroxine Replacement, a Randomized

Placebo-Controlled Study

Just another note: The raising of FT4 levels in both of these studies concluded that there was a great improvement in the risk (much less) of developing cardiovascular disease when FT4 levels were kept at a high level and that it was the most significant marker for future problems when constantly low.

Why are these issues not considered as part of the whole diagnositc process and managment of those with low FT4 readings with or without raised TSH?

Makes my blood boil. Use one set of numbers for studies behind closed dorrs and another set of numbers for the masses who ask the questions!

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  • Its mainly because these studies are never random, they are set up WITH THE RESULTS ALREADY DECIDED!! They want a 'certain' question answering and decide on the answer they want and any other information no matter how telling - is discarded.

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