Diagnosed hypothyroid in October. Started on 50 mcg Levothyroxine for 6 weeks and increased to 100 mcg 3 weeks ago. Still no change in symptoms. Only improvement is my scalp has stopped itching. Arms and legs feel heavy as if weights attached and by the evening I need to haul myself upstairs to bed on hands and knees. Any tips on when to take medication for best effect. Told has to be taken on empty stomach first thing in morning, and no food 3 hours before or after which rather limits my choices. I also have a raised itchy rash on left shin, very localised and GP no idea at all....is this related do you think? Immune system turning on itself maybe. I feel no one is listening to me and am almost in total despair as I have gone from a very active healthy person to practically an invalid. GP says my blood work shows improvement, but I am not feeling any. I have dogs I can no longer walk, I am so unhappy.