I'm currently on 100mcg thyroxine and have been for 4 years. However in the last couple months I have started feeling the 'ridiculous' tiredness again, as oposed to normal tiredness. I used to struggle driving long distances pre being diagnosed and have started to again, even experiencing a panic attack on the motorway.....I am the most laid back person normally and nothing phases me! I feel angry all the time and slightly depressed. I hardly eat due to putting 2 stone on initially with my thyroid and not being able to shift it even with gym 4/5 times a week and NO bad fat in my diet yet have started putting weight on AGAIN!! My thryoid has just been retested and come back at TSH 3.5 and T4 16.9. My Dr has suggest I 'lower' my medication. Does this sound right to anybody??