We've just got comfortable with thyroid hormones, and TSH, and deiodinases, and conversions,
We know of the hypothalamus, TRH, multiple forms of TSH, glycosylation, etc.
And then along comes a complete outsider threatening to become super-important!
Please understand, I post these things out of interest, but also to underscore the dreadfully naive view of the HPT axis (hypothalamus-pituitary-thyroid) and all thyroid hormones exhibited by endocrinologists everywhere. And that GP understanding often doesn't even reach the level of Janet and John 'I Know a Story'.
You and I might not understand more than the odd word here. But we might well realise that it adds a whole extra dimension to the already fiendishly complicated systems we already appreciate exist.
I physics, it might be like having reached an understanding of space-time and quantum effects, someone adds a fifth dimension...
QRFP43 is already known to have a major part to play in pancreatic function!
Role of Melatonin, Galanin, and RFamide Neuropeptides QRFP26 and QRFP43 in the Neuroendocrine Control of Pancreatic β-Cell Function
frontiersin.org/journals/en...
QRFP43 modulates the activity of the hypothalamic-pituitary-thyroid axis in female sheep
Discussion
Following its initial identification, QRFP43 has become a focal point of extensive research, particularly regarding its role in food intake regulation. Many studies have suggested that this peptide may induce orexigenic effects in rodents, leading to increased food consumption and subsequent weight gain. At the same time, it has been suggested that the effect of QRFP43 on the body’s energy homeostasis may depend on a number of factors. Research indicates that these variables could include type of diet, caloric intake, QRFP43 administration method, hormonal status of the animals or even the specific animal model utilised in experiments32–34. Regulation of the body’s energy equilibrium is recognised as a highly complicated process involving many systems, hormones and neurotransmitters. The HPT axis, besides the satiety and hunger centre situated in the hypothalamus, stands as a pivotal regulator of energy status, directly and indirectly influencing metabolic regulation in all cells of the body. Consequently, conducting studies aimed at elucidating how QRFP43 can affect the secretory activity of the HPT axis are of great importance.
