Very informative paper about the interactions between thyroid hormones and other hormones

[ERIC107]

Hello fellow thyroid folks!

I've recently linked to this paper in a reply to another forum member, but thought I'd do a separate post as it may not be seen as part of a reply thread.

I have found the following journal paper very informative regarding "cross-talk" between thyroid hormones and other hormones. There are some nice, clear diagrams and a helpful summary table.

It should be noted that the authors are coming from the point of view of female reproduction, and that is how they frame many of their comments, BUT there are sections that cover androgens, and other hormones relevant to both sexes (e.g. prolactin that can affect both females and males), so I believe it could be of interest to all forum members.

pubmed.ncbi.nlm.nih.gov/352...

Abstract

Accumulating evidence has shown that thyroid hormones (THs) are vital for female reproductive system homeostasis. THs regulate the reproductive functions through thyroid hormone receptors (THRs)-mediated genomic- and integrin-receptor-associated nongenomic mechanisms, depending on TH ligand status and DNA level, as well as transcription and extra-nuclear signaling transduction activities. These processes involve the binding of THs to intracellular THRs and steroid hormone receptors or membrane receptors and the recruitment of hormone-response elements. In addition, THs and other reproductive hormones can activate common signaling pathways due to their structural similarity and shared DNA consensus sequences among thyroid, peptide, and protein hormones and their receptors, thus constituting a complex and reciprocal interaction network. Moreover, THs not only indirectly affect the synthesis, secretion, and action of reproductive hormones, but are also regulated by these hormones at the same time. This crosstalk may be one of the pivotal factors regulating female reproductive behavior and hormone-related diseases, including tumors. Elucidating the interaction mechanism among the aforementioned hormones will contribute to apprehending the etiology of female reproductive diseases, shedding new light on the treatment of gynecological disorders.

[TiggerMe Ambassador]

Excellent, thanks

[RedApple]

Thanks for posting this ERIC107

This link goes to the full paper, which has diagrams too. pmc.ncbi.nlm.nih.gov/articl...

[ERIC107 in reply to RedApple]

Thank you RedApple - I have the pdf and did a quick Google to get the link. Sadly, I didn't properly check that I'd link through to the actual paper... I appreciate you putting the correct link 🙏

[helvella]

The diagrams of what happens regarding T3 within a cell shows what is so wrong about current thyroid hormone medicine.

T3 is essential for the proper functioning of our cells. And that is every single cell we possess. The impact is on gene expression and protein creation. The absolute fundamentals of life processes.

And we already know that T3 affects the metabolic rate - the energy economy of life.

It is absolutely 100% fundamental to everything.

Yet all that matters is whether our TSH is within an artificial and potentially very non-physiological range.

[Tina_Maria]

Thanks for sharing this interesting paper.

Thyroid hormones play a pivotal role in our organism and are connected to many other processes essential to balance and well-being.

Yet it seems that physicians just do not understand (or do not care about) this interconnectivity and focus on trivialities, instead of seeing the bigger picture.

I think we should lobby that medical students have to take a special course in their curriculum to properly educate them on thyroid diseases and not just a 30 min talk on the geniality of the TSH test!

[klr31]

I've often wondered whether low thyroid can be a link with breast cancer in women.

Karen

[Come-back-thyroid]

Thank you for posting this. I’ve always thought that my thyroid problems were triggered by the menopause as I wasn’t aware of any problems before menopause.

I also wonder whether as females we need different doses at different times of the month to cater for changing female hormones during the monthly cycle. We need much more research in this area but it’s good it’s starting to be looked into.

[ERIC107 in reply to Come-back-thyroid]

I think you're very likely correct... it seems logical that as different hormone levels "wax and wane" then the different levels of cross-talk would come into play, leading to different levels of thyroid hormone being available at any given point in a hormone cycle.

[Sharoosz]

Would love it if scientists could write a little more in plain English (I teach English and probably didn't understand 10% of the vocab in the article.) However, there's some interesting bits there, which bring up more questions than answers. Maybe women with period problems should be tested for thyroid issues, can some cancers be prevented with testing and thyroid treatment, how does adrenal burnout connect to thyroid issues and so on and so on. Our bodies are so unbelievably complex (amazing how well God designed us), so that if one thing gets off, so much else does too. I hope they find more about the root causes of thyroid issues through their research. Pharma unfortunately doesn't want to find the root cause of anything - it's more profitable to mask symptoms with a drug that usually causes other problems.