Low Thyroid Hormone Sensitivity Associated With Increased Mortality Risk

[buddy99]

I have not had time to thoroughly read and examine this paper, but it sounds interesting: etj.bioscientifica.com/view...

[DippyDame]

Will be interested in your views when you have thoroughly read this paper.

[buddy99 in reply to DippyDame]

Okay, I will try to remember to give my views. It's always very interesting to see what you have to say.

High mortality risk is not my favourite thing to occupy my brain with

[Bearo]

Started to read the abstract but realised I’m confused by the term ‘sensitivity to thyroid hormones’. So if you’re sensitive you respond well…make changes easily..?

Insensitive , your hormones are slow to change? A bit resistant to treatment?

Don’t think I’m getting the meaning here!

[buddy99 in reply to Bearo]

Sorry. Yeah, I find it a hard read myself. It seems to require some extra work to really get into what they have been doing. I was hoping somebody here would go, "That's the stuff!" and just start commenting to get my thinking flowing. So far no takers. I guess I have to figure it out when I have a whole lot of time on my hands.

Cute cat, by the way.

[arTistapple in reply to Bearo]

That was my reaction too. It never became clear throughout the paper. I was hoping some else could clarify. Unless the meaning is the actual opposite to the one I hold myself, it makes no sense at all! I have to literally mirror my thinking. Nah can’t do it.

[buddy99]

At least there seem to be some "nuggets" of wisdom in the Introduction. Such as, "A Chinese study of 264 sarcopenic patients aged 80 years and older found that in a euthyroid population, those with lower levels of free triiodothyronine (FT3) had a higher risk of mortality".

Anyway, so far what I understand is, that impaired sensitivity to thyroid hormones is when the tissue that should "welcome" the hormones does not sufficiently respond to them. In my own lay person's words, "the batteries can never be fully loaded", which, I think, obviously causes all sorts of problems.

Whether I fully understand this whole thing yet or not, I feel that it definitely defies the "one-fits-all" mentality and acknowledges that there is much, much more to learn about the intricacies and interplay of thyroid hormones with the rest of the body, especially the hpa axis and the sensitivity of cells. This is my understanding so far. I'm not sure I can go much further than that without spending a whole lot of time trying to find a lot of new information on the scientific terms etc. in this paper.